Gastroesophageal Reflux

Heartburn

esomeprazole 20 mg

Dep. Medicine II, University Hospital Mannheim

Esomeprazole and Gastric Emptying of Beer

Effects of Esomeprazole on Gastric Emptying of Alcoholic Beverages, Blood Alcohol Concentrations, Gastroesophageal Reflux and Release of Some Gastrointestinal Hormones in Healthy Volunteers

Heidelberg University

200 U of Botox injected endoscopically into pylorus

Received 200U of Botox injected into pyloric sphincter endoscopically.

Botulinum Toxin

Received 5 cc saline injected into pyloric sphincter endoscopically.

Placebo

Total

Sex: Female, Male

Region of Enrollment

Scale for GI symptoms related to gastroparesis. For this we will use the gastroparesis cardinal symptom index (GCSI).
The GCSI is based on three subscales: post-prandial fullness/early satiety (4 items); nausea/vomiting (3 items), and bloating (2 items). Scores range from 0-5 for the nine items and an asymptomatic patient would have a score of 0 with a highly symptomatic patient having a score of 45. For this study the score had to be >=27. In a previous study internal consistency reliability was 0.84 for the GCSI total score and ranged from 0.83 to 0.85 for the subscale scores. Two week test retest reliability was 0.76 for the total score and ranged from 0.68 to 0.81 for subscale scores.

Botox

Symptom Response as Assessed by the Gastroparesis Cardinal Symptom Index.

Overall Study

Frank Friedenberg

Gastroparesis

200 U given by injection into the pylorus.

Botulinum toxin A

Temple University Hospital

Placebo Controlled Trial of Botulinum Toxin for Gastroparesis

Randomized Placebo-Controlled Double Blind Study of Botulinum Toxin Versus Placebo for the Treatment of Gastroparesis

robin/misselijkheid

Esomeprazole and Gastric Emptying of Beer

Placebo Controlled Trial of Botulinum Toxin for Gastroparesis

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