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Plasma tumor necrosis factor and post-traumatic hyperdynamic sepsis evoked by endotoxin.

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To examine the role of systemic plasma tumor necrosis factor (TNF) in the septic response following trauma, an endotoxin (lipopolysaccharide (LPS)) challenge was administered to anesthetized mongrel pigs 72 h following either hemorrhagic shock/resuscitation or sham shock. For TNF to be considered a

Paroxysmal autonomic dysregulation with fever that was controlled by propranolol in a brain neoplasm patient.

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Intractable fever in cancer patients is problematic and the causes of this fever can be diverse. Paroxysmal persistent hyperthermia after sudden mental change or neurologic deficit can develop via autonomic dysregulation without infection or any other causes of fever. Paroxysmal hyperthermic

Infantile mediastinal primary endodermal sinus tumour.

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Primary extragonadal mediastinal endodermal sinus tumour is rare, and to date very few cases have been reported in the literature. We present here a case of rare extragonadal highly malignant commonest germ cell tumour in an infant who presented with a rapidly progressive mediastinal mass with dry

[Pulmonary Tumor Thrombotic Microangiopathy in a Patient with Metastatic Gastric Cancer].

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METHODS A 53-year-old woman with relapsed metastatic gastric cancer after multimodal therapy was hospitalized 6 months after the end of treatment due to acute dyspnea. METHODS The examination showed tachycardia and tachypnea. D-dimers and LDH were elevated, blood gases were still in the standard

Sequential changes in vital signs and acid-base and blood-gas profiles in Pneumocystis carinii pneumonitis in children with cancer. Basis for a scoring system to identify patients who will require ventilatory support.

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Early reliable identification of patients with Pneumocystis carinii pneumonia (PCP) who will require ventilatory support would be desirable. To develop a predictive system to meet this need, we studied, prospectively, the sequential alterations in vital signs and acid-base and blood-gas profiles

Nursing assessment and management of dyspneic patients with lung cancer.

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Dyspnea is a subjective sensation of breathlessness. This distressing symptom is experienced by many patients with lung cancer and often is accompanied by physiologic signs and symptoms, such as tachypnea, tachycardia, pallor, and cyanosis. Dyspnea-induced hypoxia may occur and cause confusion,

Coma from fat embolism syndrome after hemiarthroplasty of the hip for metastatic breast cancer to the proximal femur: a case report.

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We present a case report of fat embolism syndrome (FES) that resulted in prolonged coma after cemented hemiarthroplasty in a patient with metastatic breast cancer. After the cemented hip prosthesis was placed, the patient developed decreased sensorium that progressed to coma in association with

Tumor necrosis factor causes microvascular protein leakage independently of neutrophils or mast cells.

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Tumor necrosis factor-alpha (TNF-alpha) has been implicated as an important mediator in the development of multiple system organ failure after either severe injury or infection. Using the rat cremaster muscle, we previously showed that systemically administered TNF-alpha caused hypotension,

The usefulness of procalcitonin and C-reactive protein as early diagnostic markers of bacteremia in cancer patients with febrile neutropenia.

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OBJECTIVE Procalcitonin (PCT) and C-reactive protein (CRP) are well known inflammatory markers. This study was designed to determine whether PCT and CRP are useful as early diagnostic markers for bacteremia in cancer patients with febrile neutropenia (FN) in the emergency department (ED). METHODS In

Pulmonary tumor thrombotic microangiopathy associated with right ventricular rupture and hemopericardium: A case report.

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Pulmonary tumor thrombotic microangiopathy is a rare form of pulmonary tumor embolism clinically indistinguishable from pulmonary thromboembolic disease. It is characterized by fibrocellular intimal proliferation of small pulmonary arteries and arterioles in patients with intraluminal tumor

Hemifacial seizure of cerebellar ganglioglioma origin: seizure control by tumor resection.

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The cerebellum is known to have an inhibitory effect on seizures. Nevertheless, cerebellar dysplastic lesions can be epileptogenic. A 4-month-old infant had paroxysmal facial contractions; tachypnea and nystagmoid eyeball and tremulous movements were occasionally combined. These evolved to

[Early diagnosis and treatment of anastomotic leak after rectal cancer surgery].

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Anastomotic leakage is the most common major complication after mid-low rectal cancer surgery. Due to lack of knowledge regarding the virtual mechanisms of anastomotic leakage, not much can be done to prevent its development. The aim of the present review was to discuss the prevention, early

Induction of tumor necrosis factor-alpha as a cause of bleomycin-related toxicity.

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BACKGROUND The application of bleomycin is characterized by acute side effects, such as fever, chills, and sometimes hypotension and tachypnea. Furthermore, bleomycin is known to induce pneumonitis. There are several indications that the induction of cytokines by bleomycin is involved in the

How effective are supplementary doses of opioids for dyspnea in terminally ill cancer patients? A randomized continuous sequential clinical trial.

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Supplementary doses of opioids are recommended to relieve dyspnea in terminally ill cancer patients. We conducted a randomized continuous sequential clinical trial to evaluate their efficacy. We recruited 33 terminally ill cancer patients from three palliative care centers, all of whom had

Treatment with recombinant human tumor necrosis factor-alpha protects rats against the lethality, hypotension, and hypothermia of gram-negative sepsis.

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Tumor necrosis factor (TNF) is a peptide secreted by macrophages in response to endotoxin that can produce many of the changes seen in septic shock. After cecal ligation and puncture (CLP) rats gradually develop tachycardia, hypotension, tachypnea, and hypothermia. At 5 h post-CLP, rats have a peak

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