urea/hypoxie

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Exposure to acute severe hypoxia leads to increased urea loss and disruptions in acid-base and ionoregulatory balance in dogfish sharks (Squalus acanthias).

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The effects of acute moderate (20% air O2 saturation; 6-h exposure) and severe (5% air O2 saturation; 4-h exposure) hypoxia on N-waste, acid-base, and ion balance in dogfish sharks (Squalus acanthias suckleyi) were evaluated. We predicted that the synthesis and/or retention of urea, which are active

Effect of urea-hydrogen peroxide on hypoxia in rabbits.

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PaO2 in hypoxemic rabbits was raised 30 min after intravenous administration of urea-hydrogen peroxide (U-H2O2). Peak levels appeared 2 h after administration of the drug and the effect continued up to 4 h. The treatment was effective and no side effects in the rabbits were observed. A new technique

Glucose and urea metabolic enzymes are differentially phosphorylated during freezing, anoxia, and dehydration exposures in a freeze tolerant frog.

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Vertebrate freeze tolerance requires multiple adaptations underpinned by specialized biochemistry. Freezing of extracellular water leads to intracellular dehydration as pure water is incorporated into growing ice crystals and also results in the cessation of blood supply to tissues, creating an

Placental clearance of antipyrine and urea during hypoxia and adrenaline infusions in sheep [proceedings].

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Effect of hypoxia on urea synthesis in neonatal rat liver in vitro.

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Brain volume studies in animals: effects of hypercarbia, hypoxia, and intravenous urea.

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Effects of mannitol and urea on experimental cerebral anoxia.

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Hypoxia-preconditioned MSCs Have Superior Effect in Ameliorating Renal Function on Acute Renal Failure Animal Model.

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Acute renal failure (ARF) is a serious disease characterised by a rapid loss of renal functions due to nephrotoxic drug or ischemic insult. The clinical treatment approach such as dialysis techniques and continuous renal enhancement have grown rapidly during past decades. However,

Up-regulation of hypoxia inducible Factor-1α in patients with diabetic nephropathy.

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To study the role of hypoxia inducible factor-1α (HIF-1α) in patients with diabetic nephropathy (DN).In total, 133 participants were selected to conduct the investigation, parameters such as fasting blood sugar (FBS), blood urea nitrogen (BUN), and urine

Netrin-1 attenuates the progression of renal dysfunction by inhibiting peritubular capillary loss and hypoxia in 5/6 nephrectomized rats.

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OBJECTIVE The aim of this study was to investigate the effect of netrin-1 on peritubular capillary (PTC) loss and hypoxia in 5/6 nephrectomized (Nx) rats. METHODS Male Sprague-Dawley rats were divided into three groups (n = 10 rats/group): sham-operated rats treated with control adenovirus; 5/6 Nx

Cyclosporin A causes a hypermetabolic state and hypoxia in the liver: prevention by dietary glycine.

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Acute cyclosporin A (CsA) treatment inhibits mitochondrial respiration, yet effects of chronic treatment remain unclear. Accordingly, the effects of chronic CsA on oxygen metabolism in perfused rat liver and isolated mitochondria were investigated. Basal rates of oxygen uptake of around 120

Central venous hypoxemia is a determinant of human atrial ATP-sensitive potassium channel expression: evidence for a novel hypoxia-inducible factor 1alpha-Forkhead box class O signaling pathway.

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ATP-sensitive potassium channels couple cell excitability to energy metabolism, thereby providing life-saving protection of stressed cardiomyocytes. The signaling for ATP-sensitive potassium channel expression is still unknown. We tested involvement of biochemical and biophysical parameters and

Celecoxib modulates nitric oxide and reactive oxygen species in kidney ischemia/reperfusion injury and rat aorta model of hypoxia/reoxygenation.

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OBJECTIVE This study investigated the interaction between COX-2, NO and ROS after ischemia/reperfusion events in the kidney and vascular beds. METHODS Kidney IRI model in male Sprague-Dawley rats was used and various biochemical and histopathological parameters were examined. The isolated rat aortic

Renal cellular hypoxia in adenine-induced chronic kidney disease.

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We determined whether adenine-induced chronic kidney disease (CKD) in rats is associated with renal tissue hypoxia. Adenine (100 mg) or its vehicle was administered to male Sprague-Dawley rats, daily by oral gavage, over a 15-day period. Renal function was assessed before, and 7 and 14 days after,

Effect of prostaglandin E2 on urea synthesis and hepatic hemodynamics in rat livers. An in vivo/in vitro study.

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The study was carried out on 30 rats. PGE2 was found to inhibit both the ammonium uptake and urea formation by hepatocytes, i.e. PGE2 inhibited the ornithine cycle in a non-recirculating perfusion of the liver. Simultaneously PGE2 inhibited liver oxygen uptake and raised portal pressure. Inhibition

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