The Health Effect of Diet Rich in Nordic Berries
Nøkkelord
Abstrakt
Beskrivelse
Berries are traditionally an important part of the Nordic diet. About 50 different berries are grown in the northern region, and about half of them are edible. Phenolic compounds are one of the most diverse group of secondary metabolites present in edible plants, and berries are especially rich in them. Flavonoids, phenolic acids, lignans and complex phenolic polymers (polymeric tannins) are typical for berries. Phenolic compounds are reported to have a variety of beneficial biological properties. They are potent antioxidants, and exhibit various other physiological activities including anti-inflammatory, antimicrobial, antiallergic, anticarcinogenic and antihypertensive activities. Epidemiological studies indicate that diet rich in phenolic compound correlates with lower risk of cancer and cardiovascular disease.
The aim of the present study is to examine the effect of diet rich in berries on glucose and lipid metabolism and inflammatory markers and gene expression profile in peripheral blood mononuclear cells (PBMCs) in subjects with features of metabolic syndrome.
Randomized, controlled clinical intervention including 4 wk run-in period, 8 wk dietary intervention and 4 wk recovery period was conducted.
Datoer
| Sist bekreftet: | 04/30/2018 |
| Først sendt: | 08/09/2011 |
| Anslått påmelding sendt: | 08/09/2011 |
| Først lagt ut: | 08/10/2011 |
| Siste oppdatering sendt: | 05/11/2018 |
| Siste oppdatering lagt ut: | 05/16/2018 |
| Faktisk studiestartdato: | 12/31/2005 |
| Anslått primær ferdigstillelsesdato: | 11/30/2006 |
| Anslått sluttdato for studien: | 02/28/2010 |
Tilstand eller sykdom
Intervensjon / behandling
Dietary Supplement: SRC
Dietary Supplement: BB
Other: C
Fase
Armgrupper
| Væpne | Intervensjon / behandling |
|---|---|
| Experimental: SRC Strawberry, raspberry and cloudberry intervention for 8 weeks | Dietary Supplement: SRC 100 g of strawberry puree, 100 g of frozen raspberries and 100 g frozen cloudberries were concumed daily for 8 weeks. Bilberry consumption was restricted. |
| Experimental: BB Bilberry intervention for 8 weeks | Dietary Supplement: BB Equivalent amount to 400 g of fresh bilberries were consumed as 40 g of dried bilberries and as 200 g of frozen bilberries. Restriction of use of strawberries, raspberries and cloudberries were set. |
| Experimental: C Control diet with restricted berry consumption | Other: C Control diet, ie. habitual diet with restriction of berry consumption was consumed for eight weeks |
Kvalifikasjonskriterier
| Alder Kvalifisert for studier | 50 Years Til 50 Years |
| Kjønn som kan studeres | All |
| Godtar sunne frivillige | Ja |
| Kriterier | Inclusion Criteria: - overweight (BMI 26-39 kg/m2), and two of the following: - elevated fasting plasma glucose in the absence of diabetes (5.6-6.9 mmol/l) - abnormal serum lipid concentration: fasting serum triglyceride concentration >1.7 mmol/L, fasting serum HDL cholesterol <1.0 mmol/L (males) or <1.3 mmol/L (females)) - waist circumference >102 cm (males) or >88 cm (females) - blood pressure >130/85 mmHg Exclusion Criteria: - chronic diseases - use of lipid lowering medication |
Utfall
Primære utfallstiltak
1. Glucose level [week 8]
2. Cholesterol level [week 8]
3. Inflammation markers [week 8]
Sekundære utfallstiltak
1. Markers of sterol metabolism [week 8]
2. gene expression in PBMCs [study week 8]
