[Study on the pharmacokinetics and bioavailability of syringic acid in rabbits].

OBJECTIVE

To study the pharmacokinetics and bioavailability of syringic acid(SA) in rabbits by HPLC.

METHODS

After the rabbits were injected SA injection via ear vein and peritoneal cavity, blood was collected also via ear vein at different time-point. Then the concentration of SA in blood was determined by HPLC and the concentration-time curve was mapped to simulate a compartment model. So the pharmacokinetic parameters were calculated out. Several days after this injection, the drug was administered to the rabbits via i.p. and using the same method, another concentration-time curve was obtained. By comparing the AUC of the two curves, bioavailability was obtained.

RESULTS

The concentration-time curve of SA in rabbits after i.v. fitted in a two-compartment open model and the absolute bioavailability was 86.27%.

CONCLUSIONS

The results were valuable for the clinical application of new anti-endotoxic drug from Radix Isatidis.