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Side 1 fra 46 resultater
Developmental and interactive effects of arsenic and chromium to developing Ambystoma maculatum embryos: Toxicity, teratogenicity, and whole-body concentrations.
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Anthropogenic activity has contributed to elevated environmental concentrations of arsenic (As) and chromium (Cr). The spotted salamander, Ambystoma maculatum, may be useful for identifying developmental effects produced by exposure to these contaminants as adults breed and larvae develop in water
Toxic epidermal necrolysis after extensive dermal use of realgar-containing (arsenic sulfide) herbal ointment.
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BACKGROUND
Realgar (arsenic sulfide) is thought to be safe with few reports on toxicities or adverse effects and has been used in Traditional Chinese Medicine for many centuries. Serious realgar poisoning is rare, and we report a fatal case resulted from short-term use of realgar-containing herbal
Cytogenetic evaluation of arsenic trioxide toxicity in Sprague-Dawley rats.
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Acute exposure to arsenic trioxide has been reported to induce death and/or multiple organ damage with symptoms including nausea, vomiting, diarrhea, gastrointestinal hemorrhage, cerebral edema, tachycardia, dysrhythmias and hypovolemic shock. Its toxic effects are due to its ability to bind to
Health effect levels for risk assessment of childhood exposure to arsenic.
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Health risks to children from chemicals in soil and consumer products have become a regulatory focus in the U.S. This study reviews short-term health effect levels for arsenic exposure in young children (i.e., 0-6 years old). Acute health effects are described mostly in adults in case reports of
Acute arsenic poisoning: clinical, toxicological, histopathological, and forensic features.
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This report describes a suicide case by acute arsenic intoxication via intravenous injection. A 30-year-old woman injected arsenic As (V) (sodium arseniate disodique: Disodium Hydrogena Arsenik RP) in a successful suicide attempt. Three hours following administration, the woman developed severe
Arsenic impairs embryo development via down-regulating Dvr1 expression in zebrafish.
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Exposure to environmental inorganic arsenic compounds has serious health effects on humans, including cancer, cardiovascular disease, developmental and reproductive problems. Our previous study showed that arsenic exposure caused various signs of toxicity in early stages of zebrafish development,
Studies on the clinical efficacy and pharmacokinetics of low-dose arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia: a comparison with conventional dosage.
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Twenty cases of patients with relapsed acute promyelocytic leukemia (APL) were entered into this study for evaluating the clinical efficacy and pharmacokinetics of low-dose arsenic trioxide (As2O3). As2O3 was given at a daily dose of 0.08 mg/kg intravenously for 28 days. Pharmacokinetic study was
Acute toxicity of intratracheal arsenic trioxide instillation in rat lungs.
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This study investigated the acute toxicity of different concentrations of arsenic trioxide (As2 O3 ; ATO) on rat lungs. In total, 160 Wistar rats were randomly divided into the control, low-, medium- and high-dose groups, which were exposed to 0, 0.16, 1.60 and 16 μg/kg of ATO
Retinoic acid syndrome induced by arsenic trioxide in treating recurrent all-trans retinoic acid resistant acute promyelocytic leukemia.
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Arsenic Trioxide (As2O3) is an effective agent for treating acute promyelocytic leukemia achieving a complete remission rate of about 60% to 90%. It is similar to all-trans retinoic acid (ATRA) when treating acute promyelocytic leukemia (APL), because both agents have limited side effects compared
[Preliminary study of Realgar and arsenic trioxide on gut microbiota of mice].
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The aim of this paper was to observe the effect of Realgar and arsenic trioxide on gut microbiota. The mice were divided into low-dose Realgar group(RL), medium-dose Realgar group(RM), high-dose Realgar group(RH), and arsenic trioxide group(ATO), in which ATO and RL groups had the same trivalent
Histopathological Changes in Arsenic Kushta Induced Nephrotoxicity in Wistar Rats.
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To determine the nephrotoxic effects of arsenic kushta (Kushta Sam-ul-Far) in Wistar rats.
Experimental study.
Department of Morbid Anatomy and Histopathology, University of Health Sciences, Lahore from May to August 2014.
This experimental study was conducted on 48 healthy Wistar rats, each
Acute lung injury induced by arsenic trioxide in a patient with refractory myelodysplastic syndrome.
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Arsenic trioxide has been used successfully for the treatment of refractory acute promyelocytic leukemia and has shown promise in the treatment of myelodysplastic syndrome (MDS), although it is not a labeled indication. Retinoic acid syndrome is manifested by fever, dyspnea, peripheral edema,
[Arsenic trioxide in combination with all-trans retinoic acid for acute promyelocytic leukemia: a systematic review and meta-analysis].
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BACKGROUND
The studies have demonstrated that arsenic trioxide (ATO) in combination with all-trans retinoic acid (ATRA) takes effects in treatment of acute promyelocytic leukemia (APL) through different underlying mechanisms. This has established the molecular foundation of ATO plus ATRA therapy.
[Efficacy of arsenic trioxide for acute promyelocytic leukemia: a systematic review and meta-analysis].
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OBJECTIVE
To systematically review the efficacy and safety of arsenic trioxide (ATO) in treatment of acute promyelocytic leukemia (APL).
METHODS
The Cochrane Library (Issue 1, 2009), Cochrane Central Register of Controlled Trials (from 1970 to January 2009), MEDLINE (from 1978 to October 2008),
Teratogenicity, genotoxicity and oxidative stress in zebrafish embryos (Danio rerio) co-exposed to arsenic and atrazine.
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Arsenic and atrazine are common environmental contaminants probably due to their extensive use as pesticides on agricultural farmlands. In this study, zebrafish embryos were exposed to 0.8mM arsenic, 0.1mM atrazine or mixture of both for 96h, and various indices which are indicative of
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