ergotamine/seizures

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The effect of ergotamine and methysergide on serotonin metabolism in the rat brain.

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Ergotamine tartrate and methysergide maleate each significantly altered serotonin (5-HT) metabolism in the rat brain. Whole brain levels of 5-HT were markedly reduced in a dose-related manner, with peak activity observed 30 minutes after I.P. administration and persisting through four hours after

Seizure after use of almotriptan.

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We report the case of a young woman who suffered from a seizure after use of almotriptan. There was a recurrence with ergotamine. We discuss possible link with susceptibility genes.

[Intractable vomiting, convulsions and megaloblastic anemia: anamnesis, key to diagnosis].

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In July 1996 a 43-year-old illiterate Hispanic woman presented with uncontrollable vomiting, palpitations and confusion. In 1994, despite several hospitalisations in other medical centres where a cerebral CT-scan, oesogastroduodenoscopy, colonoscopy and abdominal ultrasound were performed, no

Pharmacological rationale for the clinical use of caffeine.

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Caffeine is widely consumed in beverages to obtain mild CNS stimulant effects. Long term use produces tolerance to some of the pharmacological effects. Withdrawal of caffeine, even from moderate intake levels, can produce symptoms such as headache, fatigue and anxiety. Caffeine is used

The patient with medication overuse: clinical management problems.

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Patients with chronic headache arise many problems in clinical management, often strictly related to medication overuse. IHS classification did not clear the different clinical presentation and a chapter dedicated to this problem is lacking. This condition is very frequently associated with

Management of sporadic and familial hemiplegic migraine.

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Sporadic and familial hemiplegic migraines (SHM and FHM) are rare paroxysmal disorders characterized by motor aura and headache. The distinction is based on whether other family members are affected. The majority of FHM families have a mutation in one of the ion channels CACNA1A, ATP1A2 and SCN1A.

Chapter 41: the history of neurology in Scandinavia.

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Neurology is well developed in Scandinavia (Denmark, Finland, Iceland, Norway, and Sweden) with a large number of clinical departments and specialists. The care for neurological patients is fairly equally organized even if neurology has evolved from different sources, from psychiatry in Denmark and

[Multifocal brain haemorrhage associated with migraine and medication abuse].

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BACKGROUND Although ischemic stroke is a well known complication of migraine, cerebral hemorrhage has been uncommonly reported. METHODS We present the case of a 56-year-old woman with a long history of headache and abuse of ergotamine and antiinflamatory drugs who was admitted for generalized

[Sodium diphenylhydantoin as a probable cause of pancreatitis].

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BACKGROUND Drug-induced pancreatitis is much more common in children than in adults. Many drug have been implicated in its pathogenesis. Among the neuropsychiatric drugs only valproic acid, carbamazepine, clozapine and ergotamine have been reported. Phenytoin is commonly used for the treatment of

Pharmacokinetics of rectal drug administration, Part I. General considerations and clinical applications of centrally acting drugs.

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Generally, oral administration is the route of choice in the daily practice of pharmacotherapy. However, in some circumstances this is impractical or even impossible (during nausea and vomiting or convulsions, in uncooperative patients and before surgery). In these cases, the rectal route may

Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse.

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A method has been described for the study of the central effects produced by the intracerebral injection of drugs in the unanaesthetized mouse. The effects observed were in good agreement with those obtained after similar injections in cats, dogs and human beings. After intracerebral injection,

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