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5 resultater
[The correction of disorders in the pharmacodynamics of drugs metabolized in the liver in the postnatal ontogeny of rats with acute hepatitis].
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It has been established in experiments on 30 day albino rats that in acute hepatitis, the pharmacodynamics of the test drugs hexenal, amidopyrine and ethylmorphine metabolized in the liver is considerably potentiated. In contrast to silibor, phytin and zixorine, experimental therapy with benzonal
Expression of oxidative stress-related molecules in circulating leukocytes and urine in patients with chronic viral hepatitis.
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OBJECTIVE
Oxidative stress plays a role in pathogenesis of chronic viral hepatitis. Expression of oxidative stress-related molecules remains to be clarified.
METHODS
4-hydroxy-2-nonenal (4-HNE), 4-hydroxy-2-hexenal (4-HHE), catalase, superoxide dismutase-1 (SOD-1), glutathione peroxidase-1,
In situ detection of oxidized n-3 polyunsaturated fatty acids in chronic hepatitis C: correlation with hepatic steatosis.
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BACKGROUND
Oxidative stress contributes to the pathogenesis of chronic hepatitis C. The aim of this study was to assess the peroxidation of n-3 polyunsaturated fatty acids (PUFAs) in the liver and its relation to hepatic steatosis in chronic hepatitis C.
METHODS
We immunohistochemically detected
[New derivatives of triazino- and imidazoindole with hepatoprotective activity].
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The effect of 30 indole derivatives (mainly condensed) containing a thio-carbamide fragment was investigated in rats using a model of carbontetrachloride-induced hepatitis and a model of partial hepatectomy (for some compounds). Among indoles, 1,2,4-triazino[5,6-b]- and [6,5-b]indole as well as
Lipid peroxidation contributes to immune reactions associated with alcoholic liver disease.
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Increasing evidence indicates the involvement of immune reactions in the pathogenesis of alcoholic liver disease. We have investigated whether ethanol-induced oxidative stress might contribute to immune response in alcoholics. Antibodies against human serum albumin modified by reaction with
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