Norwegian
Albanian
Arabic
Armenian
Azerbaijani
Belarusian
Bengali
Bosnian
Catalan
Czech
Danish
Deutsch
Dutch
English
Estonian
Finnish
Français
Greek
Haitian Creole
Hebrew
Hindi
Hungarian
Icelandic
Indonesian
Irish
Italian
Japanese
Korean
Latvian
Lithuanian
Macedonian
Mongolian
Norwegian
Persian
Polish
Portuguese
Romanian
Russian
Serbian
Slovak
Slovenian
Spanish
Swahili
Swedish
Turkish
Ukrainian
Vietnamese
Български
中文(简体)
中文(繁體)
Side 1 fra 50 resultater
Dissimilar effects of nicotinamide and inosine, putative endogenous ligands of the benzodiazepine receptors, on pentylenetetrazol seizures in four strains of mice.
Bare registrerte brukere kan oversette artikler
Logg inn Registrer deg
In adult male albino BALB/c mice inosine (INS, 100 and 200 micrograms, intraventricularly) prolonged the latency of pentylenetetrazol (PTZ) seizures while nicotinamide (NAM) exerted an opposite effect. In adult male C57BL/6 mice INS decreased lethality after PTZ while NAM increased it. In adult male
Nicotinamide, inosine and hypoxanthine, putative endogenous ligands of the benzodiazepine receptor, opposite to diazepam are much more effective against kynurenine-induced seizures than against pentylenetetrazol-induced seizures.
Bare registrerte brukere kan oversette artikler
Logg inn Registrer deg
Nicotinamide (NAM, 1000 mg/kg), inosine (INS, 1000 mg/kg), hypoxanthine (HXT, 500 mg/kg), putative endogenous ligands of the benzodiazepine receptor, and nicotinic acid (NA, 500 mg/kg) diminished DL-kynurenine-(DL-K, 50 micrograms ICV) induced seizures in C57BL/6 adult male mice and only prolonged
Intracerebroventricular administration of inosine is anticonvulsant against quinolinic acid-induced seizures in mice: an effect independent of benzodiazepine and adenosine receptors.
Bare registrerte brukere kan oversette artikler
Logg inn Registrer deg
Inosine (INO) has an anticonvulsant effect against seizures induced by antagonists of GABAergic system. Quinolinic acid (QA) is an agonist NMDA receptors implicated in the neurobiology of seizures. In the present study, we investigated the anticonvulsant effect of intracerebroventricular (i.c.v.)
Inosine, an endogenous ligand of the brain benzodiazepine receptor, antagonizes pentylenetetrazole-evoked seizures.
Bare registrerte brukere kan oversette artikler
Logg inn Registrer deg
Partially purified extracts of bovine brain were previously found to inhibit competitively the binding of [3H]-diazepam to rat brain synaptosomal membranes. The purines inosine and hypoxanthine were subsequently identified as the compounds responsible for this inhibitory activity.
Effect of inosine on seizures induced with pentylenetetrazole, bicuculline, or picrotoxin.
Bare registrerte brukere kan oversette artikler
Logg inn Registrer deg
The effect in mice of inosine administered subcutaneously on the threshold of seizures induced with pentylenetetrazole (PTZ), bicuculline, and picrotoxin was studied, and brain inosine levels were measured. Following inosine, 1,000 mg/kg, the threshold to PTZ was increased at 10-30 min after
The benzodiazepines and inosine antagonize caffeine-induced seizures.
Bare registrerte brukere kan oversette artikler
Logg inn Registrer deg
The induction of generalized tonic-clinic seizures in mice by the methylxanthine stimulant caffeine is described. These seizures are indistinguishable in quality from those induced by pentylenetetrazol (PTZ), and pretreatment with low doses of caffeine potentiates PTZ-induced seizures.
Pentylenetetrazol seizures in mice: effect on brain inosine and hypoxanthine.
Bare registrerte brukere kan oversette artikler
Logg inn Registrer deg
Brain inosine and hypoxanthine were measured in mice at intervals following the intraperitoneal injection of pentylenetetrazol (PTZ), 100 mg/kg. These purines increased only after myoclonic jerks appeared and were maximal at the time of tonic hindlimb extension. Phenytoin and phenobarbital, which
Inosine, hypoxanthine, and seizures.
Bare registrerte brukere kan oversette artikler
Logg inn Registrer deg
Concentration of purine compounds in the cerebrospinal fluid of infants suffering from sepsis, convulsions and hydrocephalus.
Bare registrerte brukere kan oversette artikler
Logg inn Registrer deg
Catabolites of purine nucleotides were measured in the cerebrospinal fluid (CSF) of newborn infants with sepsis, seizures and hydrocephalus using isocratic reversed-phase HPLC. The inosine levels in the CSF of the infants with any of the illnesses were significantly higher when compared with the
Changes in brain adenosine during bicuculline-induced seizures in rats. Effects of hypoxia and altered systemic blood pressure.
Bare registrerte brukere kan oversette artikler
Logg inn Registrer deg
We analyzed brain tissue in 139 rats for adenosine and its metabolites, inosine and hypoxanthine, during the initial 120 seconds of seizures induced by bicuculline. We also measured ATP, ADP, AMP, phosphocreatine (PCr), and lactate. We divided the rats into four groups by adjustment of their
Adenosine deaminase in convulsions along with its regional, cellular and synaptosomal distribution in rat brain.
Bare registrerte brukere kan oversette artikler
Logg inn Registrer deg
Adenosine deaminase activity was determined in enriched neuronal, glial and synaptosomal fractions in three regions of rat brain. It was found to be equally distributed in cortical neurons and synaptosomes. Appreciable activity was observed in glial cells. A significant increase in the activity of
Electroshock raises pentylenetetrazol threshold: possible role of inosine.
Bare registrerte brukere kan oversette artikler
Logg inn Registrer deg
A series of 15 single electroshocks administered through electrodes applied to the scalp of mice raised the threshold to pentylenetetrazol-induced seizures as determined by a tail vein infusion method. The same stimulus increased brain inosine and hypoxanthine. Phenytoin, which blocks the increase
Cerebrospinal fluid purine metabolite and neuron-specific enolase concentrations after febrile seizures.
Bare registrerte brukere kan oversette artikler
Logg inn Registrer deg
If febrile seizures cause significant compromise of neuronal metabolism (whether permanent or reversible), this should be reflected in an increase in the cerebrospinal fluid concentrations of neuron-specific enolase (NSE) and/or adenosine triphosphate (ATP) breakdown products. In the present study,
Acute creatine administration improves mitochondrial membrane potential and protects against pentylenetetrazol-induced seizures.
Bare registrerte brukere kan oversette artikler
Logg inn Registrer deg
A growing body of evidence indicates that creatine (Cr) exerts beneficial effects on a variety of pathologies where energy metabolism and oxidative stress play an etiological role. However, the benefits of Cr treatment for epileptics are still shrouded in controversy. In the present study, we found
Purine metabolites and pyrimidine bases in cerebrospinal fluid of children with simple febrile seizures.
Bare registrerte brukere kan oversette artikler
Logg inn Registrer deg
Adenosine monophosphate, inosine monophosphate, inosine, adenosine, guanosine, adenine, guanine, hypoxanthine, xanthine, uric acid and pyrimidine bases were determined in the CSF of 18 children after simple febrile seizures and in a control group. There was no statistically significant difference
Den mest komplette databasen med medisinske urter støttet av vitenskap
- Fungerer på 55 språk
- Urtekurer støttet av vitenskap
- Urtegjenkjenning etter bilde
- Interaktivt GPS-kart - merk urter på stedet (kommer snart)
- Les vitenskapelige publikasjoner relatert til søket ditt
- Søk medisinske urter etter deres effekter
- Organiser dine interesser og hold deg oppdatert med nyheter, kliniske studier og patenter
Skriv inn et symptom eller en sykdom og les om urter som kan hjelpe, skriv en urt og se sykdommer og symptomer den brukes mot.
* All informasjon er basert på publisert vitenskapelig forskning
