methyl nicotinate/erythema

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Establishing a minimal erythema concentration of methyl nicotinate for optimum evaluation of anti-inflammatories.

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Topical administration of chemicals such as methyl nicotinate that induce erythema have been employed to measure the effectiveness of formulations containing anti-inflammatory agents. Prior studies have utilized a single concentration of methyl nicotinate, between 36.5 and 100 mM, for all test

Time of erythema onset after application of methyl nicotinate ointments as response parameter: influence of penetration kinetics and enhancing agents.

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The time of erythema onset may be used as a response parameter for quantification of the cutaneous erythema response induced by methyl nicotinate. The vehicles light mineral oil (LMO; test) and medium chain triglycerides (MCT; standard) were compared with regard to the pharmacodynamic response.

PUVA treatment inhibits nonimmunologic immediate contact reactions to benzoic acid and methyl nicotinate.

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The effect of trioxsalen bath PUVA therapy on nonimmunologic immediate contact reactions (NIICRs) induced by benzoic acid (BA) and methyl nicotinate (MN) was studied in 12 dermatologic patients. One half of the back skin was covered with a cloth before each of ten irradiations on subsequent days.

Assessment of skin erythema by eye, laser Doppler flowmeter, spectroradiometer, two-channel erythema meter and Minolta chroma meter.

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Visual grading, a laser Doppler flowmeter, a spectroradiometer, a two-channel erythema meter and a Minolta chroma meter were compared in the measurement of erythemas arising from immediate contact reactions produced either by 250 mM benzoic acid or 10 mM methyl nicotinate in petrolatum in an open

Persistent erythema with niacin is not attributable to aspirin resistance.

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BACKGROUND Niacin is suboptimally used in patients because it causes flushing and erythema. These side effects have been attributed to release of the vasodilating prostaglandin D2, generated in a reaction catalyzed by cyclooxygenase-1. Aspirin reduces but does not completely eliminate these side

Preparation and anti-inflammatory activity of triptolide ethosomes in an erythema model.

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BACKGROUND The aim of this work was to evaluate the suitability of ethosomes as carriers for the topical application of triptolide in a rat model of erythema. OBJECTIVE We determined the optimal conditions for preparing ethosomes, and we measured their vesicle size by a laser particle-size analyzer

Effect of charge and lipid concentration on in-vivo percutaneous absorption of methyl nicotinate from liposomal vesicles.

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We have investigated the influence of charge and lipid concentration on the in-vivo percutaneous absorption of a model compound, methyl nicotinate (MN), from liposomal vesicles. MN-loaded liposomes were produced by the reverse-phase evaporation method (REV) using different concentrations of

Skin blood flow response to topically applied methyl nicotinate: Possible mechanisms.

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Methyl nicotinate (MN) induces a local cutaneous erythema in the skin and may be valuable as a local provocation in the assessment of microcirculation and skin viability. The mechanisms through which MN mediates its vascular effect are not fully known. The aim of this study was to

Noninvasive assessments of the percutaneous absorption of methyl nicotinate in humans.

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Percutaneous penetration of the vasodilator methyl nicotinate (methyl 3-pyridinecarboxylate) has been monitored in vivo in humans with the noninvasive techniques of laser Doppler velocimetry and photopulse plethysmography. These optical methods use different technologies to generate a voltage output

Cutaneous responses to topical methyl nicotinate in human forearm and vulvar skin.

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In order to identify and define differences in percutaneous absorption and microcirculatory sensitivity between forearm and vulvar skin we studied the response of human forearm and vulvar (labium majus) skin to topical methyl nicotinate (MN) in 11 healthy premenopausal volunteers. MN-induced

The microvascular response in the skin to topical application of methyl nicotinate: Effect of concentration and variation between skin sites.

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Methyl nicotinate (MN) induces a local cutaneous erythema in the skin and may be used as a local provocation in the assessment of microcirculation and skin viability. The aims were to measure the effects of increasing doses of MN, to find the concentration that yields the most

Kinetics of release and simulated absorption of methyl nicotinate from different ointment formulations: in vitro-in vivo correlations.

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The influence of the vehicle on release and simulated absorption of methyl nicotinate (MN) was evaluated using in vitro systems in order to find a correlation with data previously obtained in vivo. Simulation of drug absorption was carried out using a porous polymer membrane soaked with lipophilic

Influence of skin colour on the detection of cutaneous erythema and tanning phenomena using reflectance spectrophotometry.

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OBJECTIVE This research aims at assessing the influence of baseline skin colour on the ability of reflectance spectrophotometry to detect cutaneous erythema induced by a low concentration of methyl nicotinate (2.5 mM) (first objective), and to detect tanning induced by ultraviolet rays (UVA+UVB) at

Systemic effect of ultraviolet irradiation on non-immunologic immediate contact reactions to benzoic acid and methyl nicotinate.

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Systemic effects of ultraviolet irradiation B (UVB) and ultraviolet irradiation A (UVA) on non-immunologic immediate contact reactions (NIICRs) induced by benzoic acid (BA) and methyl nicotinate (MN) were studied in healthy volunteers. NIICR tests with four concentrations of BA and MN in white

Effects of infra-red and neodymium yttrium aluminium garnet laser irradiation on non-immunologic immediate contact reactions to benzoic acid and methyl nicotinate.

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Effects of infra-red A (IRA) (600-2000 nm) and 1064 nm laser irradiation on non-immunologic immediate contact reactions (NIICRs) induced by benzoic acid (BA) and methyl nicotinate (MN) were studied. Five concentrations of BA and MN in petrolatum were tested, on two subsequent days, without occlusion

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