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ototoxicity/salvia
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9 resultater
Protective effects of Salvia miltiorrhiza against cisplatin-induced ototoxicity in guinea pigs.
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OBJECTIVE
The aim of the study was to investigate the protective effects of Salvia miltiorrhiza (SM) against cisplatin-induced ototoxicity in guinea pigs.
METHODS
Thirty-nine guinea pigs were randomly divided into 3 groups. The first group (control group) received physiologic saline by
[Effect of injectio Salvia Miltiorrhiza on gentamicin ototoxicity-induced activity of nitric oxide synthase in cochlear stria vascularis of guinea pig].
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OBJECTIVE
to investigate the change of nitric oxide synthase (NOS) activity in cochlear stria vascularis (SV) of guinea pig after gentamicin (GM) and Salvia Miltiorrhiza (SM) injection, and to explore the protective role of injectio SM on GM ototoxicity.
METHODS
NADPH-diaphorase histochemistry
The protective effect of Salvia miltiorrhiza on gentamicin-induced ototoxicity.
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OBJECTIVE
The clinical use of aminoglycoside antibiotics is limited in most countries because of auditory toxicity side effects. However, their use is common in developing countries because they are inexpensive and convenient. Salvia miltiorrhiza extracts are used clinically in China for their
Protective effect of tanshinone IIA against radiation-induced ototoxicity in HEI-OC1 cells.
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Radiotherapy is a highly efficient treatment method for nasopharyngeal carcinoma that is often accompanied by significant ototoxic side-effects. The inner ear hair cells are particularly prone to serious injury following radiotherapy. Tanshinone IIA is a transcription factor inhibitor that is
[Study on effects of injection Salvia miltiorrhiza against ototoxicity induced by anticancer agent of cisplatin].
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[Effects of salvia miltiorrhiza injection on gentamicin-induced expression of nitric oxide synthase isoforms in guinea pig cochlea].
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OBJECTIVE
To investigate the effects of salvia miltiorrhiza injection (SM) on gentamicin (GM)-induced expression of nitric oxide synthase (NOS) isoforms in guinea pig cochlea, and to explore the protective mechanism of SM on GM-induced ototoxicity.
METHODS
40 guinea pigs were randomly assigned to 4
[iNOS and AChE expression on guinea pigs cochlea spiral ganglion induced by streptomycin and attenuation by Salvia miltiorrhiza injection].
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OBJECTIVE
To study the expression of iNOS and AChE on ginea pigs cochlea spiral ganglion induced by streptomycin (SM) and attenuation by salvia miltiorrhiza injection (Chinese Traditional medicine-dansen DS).
METHODS
32 guinea pigs were divided into 4 groups randomly (n=8): control group, SM group,
[Effect of injection salvia miltiorrhiza on the expression of inducible nitric oxide synthase in the cochlea of guinea pig damaged by streptomycin].
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OBJECTIVE
To investigate the expression of Inducible Nitric Oxide Synthase (iNOS) in the cochlea of guinea pig after streptomycin (SM) and the antagonism of Salvia Miltiorrhiza injection on SM ototoxicity.
METHODS
Light microscope, transmission electron microscope (TEM), immunohistochemical staining
[Effects of injectio Salvia miltiorrhiza on gentamicin-induced free radical formation in guinea pig cochlea].
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OBJECTIVE
To investigate the effects of injectio Salvia Miltiorrhiza (SM) on gentamicin (GM)-induced free radical formation in guinea pig cochlea, and to explore possible mechanisms on GM-induced ototoxicity.
METHODS
Biochemical assays of superoxide dismutase (SOD) activity and malondialdehyde (MDA)
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