pediatric obesity/betennelse

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Serum levels of soluble urokinase plasminogen activator receptor as a new inflammatory marker in adolescent obesity.

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OBJECTIVE Obesity is known for low-grade inflammatory state with enhanced production of inflammatory mediators in children and adolescents. Soluble urokinase plasminogen activator receptor (suPAR) can be generated as a pro-inflammatory marker. This study was conducted to evaluate the role of suPAR,

Effects of a multidisciplinary childhood obesity treatment intervention on adipocytokines, inflammatory and growth mediators.

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OBJECTIVE To examine the effects of a 3-month multidisciplinary intervention on anthropometric measures, physical activity patterns and fitness, inflammatory cytokines, adipocytokines, and growth mediators in obese children. METHODS 21 obese subjects completed the 3-month intervention and were

Childhood overweight and asthma symptoms, the role of pro-inflammatory proteins.

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BACKGROUND Systemic inflammation is suggested as a mechanism by which overweight might induce asthma. However, few studies have linked childhood overweight, inflammation and asthma. OBJECTIVE To study the association between body mass index (BMI), asthma symptoms and pro-inflammatory

Circulating oxidized LDL and inflammation in extreme pediatric obesity.

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Oxidative stress and inflammation have not been well-characterized in extreme pediatric obesity. We compared levels of circulating oxidized low-density lipoprotein (oxLDL), C-reactive protein (CRP), and interleukin-6 (IL-6) in extremely obese (EO) children to normal weight (NW) and overweight/obese

Role of nitric oxide (NO) metabolism and inflammatory mediators in childhood obesity.

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OBJECTIVE The role of NO and adipocytokines in childhood obesity was studied, supposing that obesity provokes inflammation. Children were admitted to the pediatric clinic for a regular check up because of obesity. METHODS Obese (n = 79) and healthy (n = 12) children were selected and divided into

Weight loss and sleep-disordered breathing in childhood obesity: effects on inflammation and uric acid.

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Sleep-disordered breathing (SDB) is prevalent in childhood obesity. It may be an independent risk factor for the metabolic syndrome. Possible mechanisms are inflammation and oxidative stress. Adenotonsillectomy in childhood obesity is associated with a high recurrence rate and risk of postoperative

Impact of child obesity on adipose tissue physiology: assessment of adipocytokines and inflammatory cytokines as biomarkers of obesity.

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Obesity could be interpreted as a low grade inflammatory state. The role of cytokines for innate and acquired immune response and adipocytokines in pathogenesis of obesity is not completely understood. The aim of the study was to evaluate anthropometric parameters, adipocytokines and inflammatory

Pediatric obesity: an inflammatory condition?

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Childhood obesity has grown at an alarming rate, and concomitant with this rise there is an increasing prevalence of metabolic risk factors in young children and adolescents. These metabolic risk factors include elevated circulating triglycerides and low levels of high-density lipoprotein, but also

Metabolic, hormonal, oxidative, and inflammatory factors in pediatric obesity-related liver disease.

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OBJECTIVE To examine the role of metabolic, hormonal, oxidative, and inflammatory factors in pediatric obesity-related liver disease. METHODS In 50 obese children (age 7 to 14 years) with (n = 20, group 1) or without (n = 30, group 2) hypertransaminasemia and ultrasonographic liver brightness, we

Pro-inflammatory triggers in childhood obesity: correlation between leptin, adiponectin and high-sensitivity C-reactive protein in a group of obese Portuguese children.

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BACKGROUND Pediatric obesity is increasingly prevalent in the Portuguese population. Adipocyte dysfunction results in the expression of pro-inflammatory mediators that are responsible for the low-grade inflammatory process that characterizes obesity. OBJECTIVE The aim of this study was to

The Relations Between Immunity, Oxidative Stress and Inflammation Markers, in Childhood Obesity.

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Oxidative stress, inflammation and insulin resistance are the principal culprits in childhood obesity. Immune modifications are also important in the development of the obesity complications.The aim of this study is to find the relations for some immunity parameters with markers for oxidative stress

Adiponectin in childhood and adolescent obesity and its association with inflammatory markers and components of the metabolic syndrome.

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BACKGROUND Adiponectin levels are lower in obese children and adolescents, whereas markers of inflammation and proinflammatory cytokines are higher. Hypoadiponectinemia may contribute to the low-grade systemic chronic inflammatory state associated with childhood obesity. OBJECTIVE We investigated

Chronic Low-Grade Inflammation in Childhood Obesity Is Associated with Decreased IL-10 Expression by Monocyte Subsets.

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Chronic low-grade inflammation is related to the development of comorbidities and poor prognosis in obesity. Monocytes are main sources of cytokines and play a pivotal role in inflammation. We evaluated monocyte frequency, phenotype and cytokine profile of monocyte subsets, to determine their

Searching for Evidence of an Anti-Inflammatory Diet in Children: A Systematic Review of Randomized Controlled Trials for Pediatric Obesity Interventions With a Focus on Leptin, Ghrelin, and Adiponectin.

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To address the complex phenomenon of pediatric obesity, one must understand the physiological mechanisms regulating energy intake and inflammation. The peptide hormones leptin, ghrelin, and adiponectin are involved in both, but their functions are dysregulated in obesity. The purpose of this

Vitamin D deficiency in childhood obesity is associated with high levels of circulating inflammatory mediators, and low insulin sensitivity.

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OBJECTIVE Childhood obesity is accompanied by low-grade systemic inflammation, which contributes to the development of insulin resistance and cardiovascular complications later in life. As vitamin D exhibits profound immunomodulatory functions and vitamin D deficiency is highly prevalent in

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