3 resultater
OBJECTIVE
To investigate the role of processivity and drug-dependence of HIV-1 protease as fitness determinants in variants resistant to protease inhibitors (PI).
METHODS
HIV-1 protease sequences from 32 infected subjects (27 patients who failed PI-treatments and five PI-naive controls) were
Drugs of abuse acutely modulate the activity of mesolimbic dopaminergic neurons, projecting from the ventral tegmental area of the midbrain to the nucleus accumbens (NAc). Tissue plasminogen activator (tPA) is a serine protease that catalyzes the conversion of plasminogen (plg) to plasmin. Here we
Nicotine, a primary component of tobacco, is one of the most abused drugs worldwide. Approximately four million people die a year because of diseases associated with tobacco smoking. Nicotine rapidly reaches the brain through smoking and this leads to nicotine dependence. Drugs of abuse including