Acute Effects of Wine Consumption on Healthy Volunteers
Słowa kluczowe
Abstrakcyjny
Opis
The last few years, epidemiologic studies indicate that regular moderate consumption of alcohol is associated with lower risk of coronary heart disease and heart attack, as well as with lower mortality. More specific, a J or U-shaped association between alcohol consumption and the incidence of coronary heart disease have been suggested, which means that there was lower disease risk in moderate alcohol consumers than in abstainers or heavy drinkers.
The scientific interest was focused on wine after the term "French paradox" was introduced, in order to describe the epidemiological observation that the French suffer a relatively low incidence of coronary heart disease, despite having a diet relatively rich in saturated fats. The paradox was attributed to the moderate consumption of red wine by French. Even though many clinical studies have occurred since then, only few of them report the postprandial effect of wine, mainly focusing on the study of oxidative stress markers and endothelium dysfunction. Also, a limited number of publications refer to the postprandial wine effect upon platelet aggregation, which is an indicative marker for inflammation / thrombosis and atherosclerosis.
The limited clinical evidence prompted us to investigate the postprandial effect of wine consumption upon platelet aggregation, inflammation and oxidation markers, by undertaking a clinical study of crossover design. The subjects randomly consumed 4ml of drink [Robola or Cabernet Sauvignon or 12.5% ethanol or water]/kg of individual, parallel with a standardized meal, which consisted of 30.8% carbohydrates, 12.0% proteins and 53.1% fat. The meal total energy was 787.2 kcal.
Daktyle
| Ostatnia weryfikacja: | 05/31/2012 |
| Pierwsze przesłane: | 06/13/2012 |
| Szacowana liczba przesłanych rejestracji: | 06/21/2012 |
| Wysłany pierwszy: | 06/25/2012 |
| Ostatnia aktualizacja przesłana: | 06/21/2012 |
| Ostatnia opublikowana aktualizacja: | 06/25/2012 |
| Rzeczywista data rozpoczęcia badania: | 03/31/2011 |
| Szacowana data zakończenia podstawowej działalności: | 09/30/2011 |
| Szacowana data zakończenia badania: | 09/30/2012 |
Stan lub choroba
Interwencja / leczenie
Other: Robola, Cabernet Sauvignon wines
Faza
Kryteria kwalifikacji
| Wiek kwalifikujący się do nauki | 26 Years Do 26 Years |
| Płeć kwalifikująca się do nauki | Male |
| Przyjmuje zdrowych wolontariuszy | tak |
| Kryteria | Inclusion Criteria: - healthy - non-obese Exclusion Criteria: - smokers - those who reported slimming or any other dietary regime - abstainers from alcohol consumption - heavy drinkers - athletes - subjects who were on medication, such as aspirin, that may have an impact on platelet aggregation or surgical events that may have affected the study outcomes - participants with a known diagnosis of either hypertension or diabetes - subjects on medication |
Wynik
Podstawowe miary wyników
1. platelet aggregation [baseline]
2. platelet aggregation [30 min after standardized meal plus tested drink consumption.]
3. platelet aggregation [90 min after standardized meal plus tested drink consumption.]
4. platelet aggregation [150 min after standardized meal plus tested drink consumption]
5. platelet aggregation [210 min after standardized meal plus tested drink consumption.]
6. platelet aggregation [300 min after standardized meal plus tested drink consumption.]
7. markers of inflammation [baseline]
8. markers of inflammation [0 min after standardized meal plus tested drink consumption]
9. markers of inflammation [30 min after standardized meal plus tested drink consumption]
10. markers of inflammation [60 min after standardized meal plus tested drink consumption]
11. markers of inflammation [90 min after standardized meal plus tested drink consumption]
12. markers of inflammation [120 min after standardized meal plus tested drink consumption]
13. markers of inflammation [150 min after standardized meal plus tested drink consumption]
14. markers of inflammation [180 min after standardized meal plus tested drink consumption]
15. markers of inflammation [210 min after standardized meal plus tested drink consumption]
16. markers of inflammation [240 min after standardized meal plus tested drink consumption]
17. markers of inflammation [300 min after standardized meal plus tested drink consumption]
18. markers of inflammation [360 min after standardized meal plus tested drink consumption]
19. markers of oxidative stress [baseline]
20. markers of oxidative stress [0 min after standardized meal plus tested drink consumption]
21. markers of oxidative stress [30 min after standardized meal plus tested drink consumption]
22. markers of oxidative stress [60 min after standardized meal plus tested drink consumption]
23. markers of oxidative stress [90 min after standardized meal plus tested drink consumption]
24. markers of oxidative stress [120 min after standardized meal plus tested drink consumption]
25. markers of oxidative stress [150 min after standardized meal plus tested drink consumption]
26. markers of oxidative stress [180 min after standardized meal plus tested drink consumption]
27. markers of oxidative stress [210 min after standardized meal plus tested drink consumption]
28. markers of oxidative stress [240 min after standardized meal plus tested drink consumption]
29. markers of oxidative stress [300 min after standardized meal plus tested drink consumption]
30. markers of oxidative stress [360 min after standardized meal plus tested drink consumption]
31. PAF metabolism [0 min after standardized meal plus tested drink consumption]
32. PAF metabolism [60 min after standardized meal plus tested drink consumption]
33. PAF metabolism [90 min after standardized meal plus tested drink consumption]
34. PAF metabolism [120 min after standardized meal plus tested drink consumption]
35. PAF metabolism [180 min after standardized meal plus tested drink consumption]
36. PAF metabolism [210 min after standardized meal plus tested drink consumption]
37. PAF metabolism [240 min after standardized meal plus tested drink consumption]
38. PAF metabolism [300 min after standardized meal plus tested drink consumption]
39. PAF metabolism [360 min after standardized meal plus tested drink consumption]
Miary wyników wtórnych
1. Glucose levels [baseline]
2. Glucose levels [0 min after standardized meal plus tested drink consumption]
3. Glucose levels [30 min after standardized meal plus tested drink consumption]
4. Glucose levels [60 min after standardized meal plus tested drink consumption]
5. Glucose levels [90 min after standardized meal plus tested drink consumption]
6. Glucose levels [120 min after standardized meal plus tested drink consumption]
7. Glucose levels [150 min after standardized meal plus tested drink consumption]
8. Glucose levels [180 min after standardized meal plus tested drink consumption]
9. Glucose levels [210 min after standardized meal plus tested drink consumption]
10. Glucose levels [240 min after standardized meal plus tested drink consumption]
11. Glucose levels [300 min after standardized meal plus tested drink consumption]
12. Glucose levels [360 min after standardized meal plus tested drink consumption]
13. Insulin levels [0 min after standardized meal plus tested drink consumption]
14. Insulin levels [30 min after standardized meal plus tested drink consumption]
15. Insulin levels [60 min after standardized meal plus tested drink consumption]
16. Insulin levels [90 min after standardized meal plus tested drink consumption]
17. Insulin levels [120 min after standardized meal plus tested drink consumption]
18. lipids [baseline]
19. lipids [0 min after standardized meal plus tested drink consumption]
20. lipids [30 min after standardized meal plus tested drink consumption]
21. lipids [60 min after standardized meal plus tested drink consumption]
22. lipids [90 min after standardized meal plus tested drink consumption]
23. lipids [120 min after standardized meal plus tested drink consumption]
24. lipids [150 min after standardized meal plus tested drink consumption]
25. lipids [180 min after standardized meal plus tested drink consumption]
26. lipids [210 min after standardized meal plus tested drink consumption]
27. lipids [240 min after standardized meal plus tested drink consumption]
28. lipids [300 min after standardized meal plus tested drink consumption]
29. lipids [360 min after standardized meal plus tested drink consumption]
