Bioavailability of the Microconstituents of Natural Chios Mastiha in Healthy Adults.
Słowa kluczowe
Abstrakcyjny
Daktyle
Ostatnia weryfikacja: | 07/31/2019 |
Pierwsze przesłane: | 07/24/2016 |
Szacowana liczba przesłanych rejestracji: | 07/26/2016 |
Wysłany pierwszy: | 07/27/2016 |
Ostatnia aktualizacja przesłana: | 08/28/2019 |
Ostatnia opublikowana aktualizacja: | 08/29/2019 |
Rzeczywista data rozpoczęcia badania: | 06/30/2016 |
Szacowana data zakończenia podstawowej działalności: | 01/31/2017 |
Szacowana data zakończenia badania: | 08/31/2019 |
Stan lub choroba
Interwencja / leczenie
Other: Mastiha
Faza
Grupy ramion
Ramię | Interwencja / leczenie |
---|---|
Other: Mastiha | Other: Mastiha The volunteers will follow a low-phytochemical diet for five days, meaning that they will exclude fruits, vegetables, legumes, coffee, tea, alcoholic beverages and chocolate. On the day of the experiment and after overnight fasting, the volunteers will consume 10g of natural Mastiha and blood samples will be obtained on timepoints 0h, 30min, 1h, 2h, 4h, 6h and 24h after Mastiha intake. Until timepoint 6h, will be allowed to consume only water. Urine samples will also be collected on timepoints 0h, 4h, 8h and 24h. |
Kryteria kwalifikacji
Wiek kwalifikujący się do nauki | 20 Years Do 20 Years |
Płeć kwalifikująca się do nauki | Male |
Przyjmuje zdrowych wolontariuszy | tak |
Kryteria | Inclusion Criteria: - Age: 20-40 years old - BMI: 18.5-24.9 kg/m2 Exclusion Criteria: - BMI > 25 kg/m2 - Alcohol or drug abuse - Medication, vitamin or inorganic supplements - Vegan or macrobiotic diet before and during the study - Gastrointestinal diseases, such as IBD, peptic ulcer or GI cancer |
Wynik
Podstawowe miary wyników
1. Phenolic and terpenoid content or metabolites of Mastiha identification [The phenolic and terpenoid content or metabolites of Mastiha will be identified in plasma samples applying LC-HRMS. Data will be presented through study completion, an average of 1 year.]
2. Targeted and untargeted metabolic profile assessment [Plasma metabolites assessment with GC-MS, LC-HRMS and urine metabolites assessment with NMR will take place . Data will be presented through study completion, an average of 1 year.]
Miary wyników wtórnych
1. Oxidative stress assessment [Serum resistance to oxidation will be assessed through the CuSO4 technique, oxidised LDL levels and uric acid levels. F-2 isoprostanes determination will take place in urine samples. Data will be presented through study completion, an average of 1 year.]