Curcumin-Simvastatin-EDTA in the Treatment of Periodontitis
Słowa kluczowe
Abstrakcyjny
Opis
The present study entailed thirty patients having stage II or stage III, Grade A periodontitis with 30 intrabony defects. Patients were divided into three groups; group I was subjected to open flap debridement only. Group II was subjected to open flap debridement followed by application of curcumin-simvastatin paste (2% curcumin and 1.2% simvastatin). Group III was subjected to open flap debridement followed by 24% EDTA root surface etching and application of curcumin-simvastatin paste (2% curcumin and 1.2% simvastatin).Clinical parameters including plaque index, sulcus bleeding index, probing depth and clinical attachment level were recorded pre-surgical. Moreover, radiographic examination was performed by cone beam computed tomography (CBCT) just before the surgery . Vertical bone defects were exposed by full thickness mucoperiosteal flap following intrasulcular incision and thorough debridement was performed. Group II received local application of curcumin-simvastatin paste .Group III received curcumin-simvastatin paste after debridement and 24 % EDTA. The same initial clinical parameters were recorded three and six months postoperatively. Radiographic measurements were recorded six months post surgically.
Daktyle
| Ostatnia weryfikacja: | 07/31/2019 |
| Pierwsze przesłane: | 07/31/2019 |
| Szacowana liczba przesłanych rejestracji: | 07/31/2019 |
| Wysłany pierwszy: | 08/04/2019 |
| Ostatnia aktualizacja przesłana: | 08/03/2019 |
| Ostatnia opublikowana aktualizacja: | 08/06/2019 |
| Rzeczywista data rozpoczęcia badania: | 08/24/2016 |
| Szacowana data zakończenia podstawowej działalności: | 05/04/2018 |
| Szacowana data zakończenia badania: | 10/02/2018 |
Stan lub choroba
Interwencja / leczenie
Procedure: currettage
Drug: curcumin simvastatin paste
Drug: EDTA, curcumin and simvastatin
Faza
Grupy ramion
| Ramię | Interwencja / leczenie |
|---|---|
| Placebo Comparator: open flap debridement only surgical treatment of periodontal defects | |
| Active Comparator: curcumin and simvastatin open flap debridement followed by application of curcumin-simvastatin paste (2% curcumin and 1.2% simvastatin). | |
| Active Comparator: EDTA, curcumin and simvastatin open flap debridement followed by 24% EDTA root surface etching and application of curcumin-simvastatin paste (2% curcumin and 1.2% simvastatin). | Drug: EDTA, curcumin and simvastatin EDTA is an aminopolycarboxylic acid and a colourless, water-soluble solid |
Kryteria kwalifikacji
| Wiek kwalifikujący się do nauki | 25 Years Do 25 Years |
| Płeć kwalifikująca się do nauki | All |
| Przyjmuje zdrowych wolontariuszy | tak |
| Kryteria | Inclusion Criteria: - Patient suffering at least a single posterior 2-3 wall periodontal Pocket of depth ≥ 5 mm, attachment loss ≥3 mm, intrabony component ≥3 mm, plaque index ≤1 (Sillness and Loe, 1964) and sulcus bleeding index ≤1 (Mühlemann & Son, 1971). All these criteria were determined after phase I conventional periodontal therapy. - Systemically healthy as evidenced by burket's oral medicine health history question questionnaire (Glick et al., 2008). - Patients available during follow-up periods Exclusion Criteria: - Smoking - Patient unwilling to comply with periodontal hygienic instructions - Patients under any long-term chronic medication - Vulnerable individuals |
Wynik
Podstawowe miary wyników
1. clinical score [change from base line to 6 months]
