Non-invasive Evaluation of Myocardial Stiffness by Elastography
Słowa kluczowe
Abstrakcyjny
Opis
DESCRIPTION PROJECT SUMMARY
Three groups of patients in sinus rhythm will be studied (n total = 100 patients):
- Group 1 "healthy volunteers" (n = 40): two age classes determined ([20-40ans, n = 20] and [60-80 years, n = 20]), to obtain normal values diastolic myocardial stiffness references. The objective will be to confirm the increase with age in myocardial stiffness assessed by elastography in healthy subjects.
- Group 2 "diastolic HF" (n = 40): older patients with isolated diastolic HF (EF> 45%, 60-80 years, n = 20) and infiltrative cardiomyopathy restrictive-type amyloidosis (n = 20) . The objective will be to study the results of elastography on two separate clinical types of IC diastolic well identified.
- Group 3 "systolic HF" (n = 20): elderly patients with heart failure with impaired ejection (<45%) fraction, but no segmental dysfunction.
The evaluation of myocardial stiffness by elastography in all these patients will be compared to conventionally ultrasound and biological parameters currently used for diagnosis of elderly's diastolic HF. Our hypothesis is that myocardial stiffness assessed by SWI is a powerful parameter for predicting diastolic heart failure. To this end, a univariate and multivariate statistical analysis will be carried out from all of these data.
EXPECTED RESULTS AND OUTLOOK The current ultrasound diagnostic parameters of diastolic heart failure (ESC 2012) using Doppler (trans-mitral tissue) anatomical, or functional (strain, strain rate, speckle tracking) criteria that are dependent on load conditions and are not specific to diastolic HF. This study should demonstrate the continuity of our preclinical studies, the non-invasive assessment of myocardial stiffness by elastography is a powerful test for the detection and diagnosis of diastolic heart failure. Secondly the prognosis character of recovery rates will be studied over a large population of people with HF and FE preserved (diastolic HF) with longitudinal follow-up.
Daktyle
| Ostatnia weryfikacja: | 09/30/2017 |
| Pierwsze przesłane: | 08/23/2015 |
| Szacowana liczba przesłanych rejestracji: | 08/30/2015 |
| Wysłany pierwszy: | 08/31/2015 |
| Ostatnia aktualizacja przesłana: | 10/30/2017 |
| Ostatnia opublikowana aktualizacja: | 11/05/2017 |
| Rzeczywista data rozpoczęcia badania: | 08/31/2015 |
| Szacowana data zakończenia podstawowej działalności: | 02/28/2017 |
| Szacowana data zakończenia badania: | 06/30/2017 |
Stan lub choroba
Interwencja / leczenie
Procedure: elastography function ShearWave Imaging
Procedure: MRI
Faza
Grupy ramion
| Ramię | Interwencja / leczenie |
|---|---|
| Other: healthy volunteers to obtain normal values diastolic myocardial stiffness references. The objective will be to confirm the increase with age in myocardial stiffness assessed by elastography in healthy subjects. | |
| Other: diastolic Heart Failure older patients with isolated diastolic HF (EF> 45%, 60-80 years, n = 20) and infiltrative cardiomyopathy restrictive-type amyloidosis (n = 20) . The objective will be to study the results of elastography on two separate clinical types of IC diastolic well identified. | |
| Other: systolic Heart Failure elderly patients with heart failure with impaired ejection (<45%) fraction, but no segmental dysfunction.
The evaluation of myocardial stiffness by elastography in all these patients will be compared to conventionally ultrasound and biological parameters currently used for diagnosis of elderly's diastolic HF |
Kryteria kwalifikacji
| Wiek kwalifikujący się do nauki | 20 Years Do 20 Years |
| Płeć kwalifikująca się do nauki | All |
| Przyjmuje zdrowych wolontariuszy | tak |
| Kryteria | Inclusion Criteria: - Group 1 "healthy volunteers" (n = 40): two age classes determined ([20-40ans, n = 20] and [60-80 years, n = 20]), - Group 2 "diastolic HF" (n = 40): older patients with isolated diastolic HF (EF> 45%, 60-80 years, n = 20) and infiltrative cardiomyopathy restrictive-type amyloidosis (n = 20) - Group 3 "systolic HF" (n = 20): elderly patients with heart failure with impaired ejection (<45%) fraction, but no segmental dysfunction Exclusion Criteria: - pregnant woman - atrial fibrillation - patient with defibrillator, pacemaker - contraindication to MRI - no consent form - echography gel allergy - participation to another study |
Wynik
Podstawowe miary wyników
1. myocardial stiffness ( measured by kPa) [18 months]
