[Tribute to Paul Janssen (1926-2003): two discoveries per year"].

Paul Janssen (1926-2003) performed during fifty Years an intense pharmaceutical research activity. From 1953 to 2003, he discovered numerous new drugs in various fields of pharmacology. He widened the neuroleptic spectrum with haloperidol and risperidone, the opioid one with dextromoramide, fentanyl and its short-life derivates, constipating agents like loperamide, hypnotics, anaesthetics. In the field of anti-infectious agents, he discovered azole antifungals, parasiticides among which levamisole and mebendazole. Other therapeutic classes have been enriched by JANSSEN's works: vasodilatating agents, antihypertensive and anti-allergic drugs, etc. More recently, his research was oriented towards virology namely anti-HIV drugs. When Paul JANSSEN's life ended, his scientific production seemed to be one of the most eminent in the XXth century.