Doxylamine

Doxylamine succinate with pyridoxine has approval from the U.S. Food and Drug Administration for the first-line treatment of nausea and vomiting of pregnancy (NVP).[1] NVP affects up to 85% of women during pregnancy—it is the most prevalent medical condition during pregnancy.[2] Most patients with NVP are manageable by making alterations to diet and lifestyle factors; however, more than 30% might need fluids, vitamin supplementation, and additional treatment with an antiemetic such as doxylamine.[3] Like other antihistamines, it also has utility for the management of allergic rhinitis.[4] Allergic rhinitis is the most prevalent atopic disorder, and symptoms consist of nasal congestion, sneezing, rhinorrhea, and nasal itching.[5] Doxylamine tablets are also available over-the-counter as an approved sleep aid for insomnia.[6] Insomnia is among the most commonly encountered patient concerns, and it can have significant adverse effects on mental and physical health.[7]