The present invention relates to a process for the preparation of high purity and yield .alpha.-asarone, trans 2,4,5-trimethoxy cinnamaldehyde, 2,4,5-trimethoxy-phenyl propionone, from .beta.-asarone or .beta.-asarone rich Acorus calamus oil containing .alpha. and .gamma.-asarone by hydrogenating, followed by treatment with DDQ with or without solid support of silica gel or alumina in dry organic solvent and .alpha.-asarone can also be obtained by treating the hydrogenated product of .beta.-asarone or .beta.-asarone rich Acorus calamus with DDQ in an aqueous organic solvent to obtain an intermediate 2,4,5-trimethoxy phenyl propionone, which in turn is reduced with sodiumborohydride to obtain the corresponding 2,4,5-trimethoxy-phenyl propanol and followed by final treatment with a dehydrating agent.

Council of Scientific &amp; Industrial Research

Process for the preparation of pharmacologically active .alpha.-asarone from toxic .beta.-asarone rich acorus calamus oil

The present invention relates to neolignan (NEOLASA-I) 3-ethyl-2-methyl-3-(2",4",5"-trimethoxy-phenyl-1-(2',4',5'-trimethoxy)phen yl-1-propene and a process for the preparation of high purity, higher yield neolignan, .alpha.-asarone, 2,4,5-trimethoxy-phenyl propionone from .beta.-asarone or .beta.-asarone rich Acorus calamus oil containing .alpha. and .gamma.-asarone by hydrogenating and dimerizing by treatment with DDQ in presence of an organic acid.

alpha asarone/tatarak

Process for the preparation of pharmacologically active .alpha.-asarone from toxic .beta.-asarone rich acorus calamus oil

DDQ mediated one step dimerization of .beta.-asarone or .beta.-asarone rich Acorus calamus oil in the formation of novel neolignan

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