After randomization, 60 subjects will receive oral dexlansoprazole (Dexilant 60 mg, Takeda Co. Ltd, Tokyo, Japan) once daily before breakfast for 8 weeks. Subjects will record their symptoms (cough, globus, NCCP, heart burn, and acid regurgitation) at daytime and nighttime everyday for 8 weeks. Symptoms suspecting drug adverse effect including nausea, diarrhea, constipation, headache, dizziness, fatigue, flatulence, etc will be recorded for 8 weeks.

After randomization, 60 subjects will receive oral lansoprazole (Takepron OD 30 mg, Takeda Co. Ltd, Tokyo, Japan) once daily before breakfast for 8 weeks. Subjects will record their symptoms (cough, globus, NCCP, heart burn, and acid regurgitation) at daytime and nighttime everyday for 8 weeks. Symptoms suspecting drug adverse effect including nausea, diarrhea, constipation, headache, dizziness, fatigue, flatulence, etc will be recorded for 8 weeks.

Compare the Response Rate of Atypical GERD After PPI Therapy

evaluate the response rate (symptom free) during the 8-week PPI therapy for atypical GERD between dexlansoprazole group and lansoprazole group

dexilansoprazole (Dexilant 60 mg)

lansoprazole (Takepron OD 30 mg)

Taipei Veterans General Hospital

Comparison of the Efficiency of Two Different PPI Formula in Atypical GERD

Comparison of the Efficiency of Two Different PPI Formula in Treatment of Atypical GERD Patients, a Randomized Study

evaluate the response rate (symptom free) everyday during the 8-week PPI therapy for cough, globus sensation, NCCP, acid regurgitation, and heartburn respectively

the withdrawal or drop-out rate due to poor symptoms response or drug adverse effects

vghtpe user

Principal Investigator (and Clinical Professor)

Taipei Veterans General Hospital, Taiwan

a prospective, randomized, open-level clinical study to evaluate 8 weeks PPI response rate for atypical GERD

antitussives/biegunka

Comparison of the Efficiency of Two Different PPI Formula in Atypical GERD

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