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The concept of field cancerization has been ever changing since its first description by Slaughter et al in 1953. Field cancerization explains the mechanisms by which second primary tumors (SPTs) develop. SPTs are the tumors, which develop in the oral cavity in succession to the primary malignant
OBJECTIVE
We evaluated whether the field-in-field (FIF) technique improves the homogeneity of the target in high tangent radiation therapy (HTRT).
METHODS
This study included 30 patients. In total, 3 HTRT plans were created: 1 with conventional opposed fields (Conv-p), 1 with the FIF technique
Differences in operative procedure and knowledge of esophageal cancer exist among surgeons from different countries and regions. There is controversy in the surgical treatment of esophageal cancer, especially in the extent of lymphadenectomy. Until now, results of the three-field lymphadenectomy and
BACKGROUND
There have been many controversies about the optimal extent of lymphadenectomy for thoracic esophageal cancer, whether three-field lymphadenectomy is superior to two-field lymphadenectomy with respect to the 5-year survival rate and perioperative morbidities and mortality.
METHODS
A
The present study is aimed at comparing the planning and delivery efficiency between three-dimensional conformal radiotherapy (3D-CRT), field-in-field, forward planned, intensity modulated radiotherapy (FIF-FP-IMRT), and inverse planned intensity modulated radiotherapy (IP-IMRT). Treatment plans of
Tumor treating fields (TTFields) are increasingly used to treat newly diagnosed and recurrent glioblastoma (GBM). Recently, the authors proposed a new and comprehensive method for efficacy estimation based on singular value decomposition of the sequential field distributions. The method accounts for
The term 'field effect' (also known as field defect, field cancerization, or field carcinogenesis) has been used to describe a field of cellular and molecular alteration, which predisposes to the development of neoplasms within that territory. We explore an expanded, integrative concept, 'etiologic
Gene therapy has a great potential in cancer treatment. However, the efficacy of cancer gene therapy is currently limited by the lack of a safe and efficient means to deliver therapeutic genes into the nucleus of tumor cells. One method under investigation for improving local gene delivery is based
OBJECTIVE
To assess the effects of 3-field lymphadenectomy for esophageal carcinoma.
METHODS
We conducted a computerized literature search of the PubMed, Cochrane Controlled Trials Register, and EMBASE databases from their inception to present. Randomized controlled trials (RCTs) or observational
To provide an overview of Tumor Treating Fields (TTFields) and the Optune device in the treatment of glioblastoma multiforme as well as discuss the evolution of TTFields technology for the treatment of different tumor types.
Peer reviewed publications, proceedings, and Internet-based
There is a widespread public perception that exposure to "EMF" is linked to cancer. This concern stems largely from a few epidemiological studies that appear to show an association between cancer and residence near power lines. However, the epidemiological evidence for such a link falls far short of
Electromagnetic fields are a ubiquitous part of man's environment. Natural sources of energy have been present, and possibly have contributed to the processes of the evolution of living forms. In very recent time, however, exploitation of the properties of the electromagnetic spectrum, has added
Cancer was first associated with exposure to electromagnetic fields (EMF) in 1979 when Wertheimer and Leeper reported that children dying from cancer resided more often in homes believed to be exposed to higher EMF than did healthy control children. The risks were as high as 2.23 (1.56-3.18) 3.09
This paper discusses some of the current questions observed in updated research analyzing the association of electromagnetic fields (EMF) exposure and cancer. It reveals the predominant efforts toward obtaining more accurate levels of EMF exposure as a crucial key to gain knowledge about that
We discuss a "genomic" mechanism capable of yielding clonal malignancies (e.g. hemopoietic leukemias) without the prerequisite of multiple or single mutations. This hypothetical mechanism is based upon the anachronistic (illegal) expression of a special gene P, where P stands for "potential". P. is