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BACKGROUND
Although enterovirus 71 has caused epidemics associated with significant morbidity and mortality, its transmission has not been thoroughly investigated.
OBJECTIVE
To investigate enterovirus 71 transmission and determine clinical outcomes within households.
METHODS
Prospective family
BACKGROUND
In Taiwan, from April to July, 1998, an epidemic of hand, foot, and mouth disease associated with enterovirus 71 (EV71) occurred with fatal complications. We did a clinical study of EV71-related diseases in Taiwan.
METHODS
We studied 154 children with virus-culture confirmed EV71
BACKGROUND
Enterovirus 71 infection causes hand-foot-and-mouth disease in young children, which is characterized by several days of fever and vomiting, ulcerative lesions in the oral mucosa, and vesicles on the backs of the hands and feet. The initial illness resolves but is sometimes followed by