Chronic Rhinosinusitis

Percutaneous 2-3 mm biopsies of middle turbinate mucosae and nasal polyps will be obtained with 5 mm Thrucut® (Smith & Nephew, Memphis, TN) biopsy forceps. Generally, 2-3 specimens will be obtained from each side as in previous studies. Healthy controls and subjects with CRS without NP will have biopsies from both middle turbinates. Subjects with CRS with NP will have two nasal polyp biopsies and one middle turbinate biopsy.

Biopsy

Massachusetts General Hospital

Pathogenesis of Chronic Sinusitis in Relationship to Tobacco Smoke Exposure

To compare the expression profile of innate immune and inflammatory factor mRNA expression in the epithelial and glandular tissue compartments in 8 patients with refractory CRS versus 8 healthy control nasal middle turbinates (HC) using microarray.

To characterize and compare the bacterial microbial community in the sinus mucosal tissues from 8 patients with refractory CRS versus 8 HC subjects.

Daniel Hamilos MD

M.D.

Massachusetts Eye and Ear Infirmary

Zinc levels and hair samples will be collected.

Rhinosinusitis

University of Alabama at Birmingham

Reversal of Tobacco-Related Sinusitis

Reversal of Tobacco-Related Sinusitis (Flight Attendant Medical Research Institute (FAMRI) Young Clinical Scientist Award)

This study is focused on identifying the prevalence of passive or active smoke exposure and zinc deficiency in a cohort of patients who meet the objective and subjective guidelines for chronic rhinosinusitis set forth by the Sinus and Allergy Health Partnership.

sinusitis/− nikotyna

Pathogenesis of Chronic Sinusitis in Relationship to Tobacco Smoke Exposure

Reversal of Tobacco-Related Sinusitis

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