Efficacy of Oral Tolerance Induction to Raw Apple
Palavras-chave
Resumo
Descrição
The aim of this study was to describe an intensive ultra rush (UR) protocol of raw Golden apple (RGA) reintroduction in 28 in-patients, show the protocol's tolerance and the patients' follow-up at 2 months and 1 year. Patients with oral allergic syndrome (OAS) having resulted in raw fruits eviction were admitted to day hospital between June 1 2016 and October 31 2017.
Methods : Patients were included during the first consultation, UR was performed with RGA in day hospital performed in two institutions, the Charcot clinic and the polyclinic of Beaujolais.
Starting with 1 gram (g) of food, then by regularly doubling dose from 2g to 128g, to reach a 255g cumulative dose in a 3 hour period.
During the the post hospitalization period, patients back home had to eat ½ RGA a day during one month, then 1 RGA a day during one month, together with other rosacea fruits resumption at the end of the 5th week if UR were performed between April 15th and July 15th. A synthesis consultation was made at two months and a telephone interview at one year.
datas
Última verificação: | 09/30/2019 |
Enviado pela primeira vez: | 08/10/2019 |
Inscrição estimada enviada: | 10/02/2019 |
Postado pela primeira vez: | 10/03/2019 |
Última atualização enviada: | 10/03/2019 |
Última atualização postada: | 10/07/2019 |
Data real de início do estudo: | 05/31/2016 |
Data Estimada de Conclusão Primária: | 10/30/2017 |
Data Estimada de Conclusão do Estudo: | 10/30/2018 |
Condição ou doença
Intervenção / tratamento
Other: Allergic patients to raw apple and birch
Fase
Grupos de Armas
Braço | Intervenção / tratamento |
---|---|
Allergic patients to raw apple and birch Single-group studies about 28 patients allergic to birch and no longer eating raw rosaceae for at least 6 months. Patients brought back into contact with this family of fruits via the raw golden apple according to an Ultra-Rush protocol. | Other: Allergic patients to raw apple and birch |
Critério de eleição
Idades qualificadas para estudar | 10 Years Para 10 Years |
Sexos elegíveis para estudo | All |
Método de amostragem | Non-Probability Sample |
Aceita Voluntários Saudáveis | sim |
Critério | Inclusion Criteria: - No longer eat raw rosacea for at least 6 months due to oral allergic syndrome - With allergic rhinitis or asthma due to betulaceae pollen (SPT+ and/or IgE + to Bet v 1 > 0,10 kUA/L) - With reduced quality of life Exclusion Criteria: - With severe allergic reaction to rosacea (>Grade 3 according to Ring and Messmer's classification) - Pregnant woman - Uncontrolled asthma (FEV1 < 70%) - Immunosuppressed patient or having malignant disease, current infectious disease, or serious cardiovascular disease - Opposed to use data |
Resultado
Medidas de Resultado Primário
1. Patients' tolerance to Golden apple re-consumption according to a Visual Analogue Scale (VAS) [[Time Frame: Day 1]]
Medidas de Resultado Secundário
1. Ultra-Rush incidence on blood pressure constants (in mmHg) [[Time Frame: Day 1]]
2. Ultra-Rush incidence on pulse rate (in bpm) [[Time Frame: Day 1]]
3. Ultra-Rush incidence on peak-flow (in liters/mn) [[Time Frame: Day 1]]
4. Procedure's safety on side effects according to a Visual Analogue Scale (VAS) [[Time Frame: Day 1]]
5. Tolerance of apple re-consumption on a daily basis during the 2 months following ultra-rush [[Time Frame: Day 1]]
6. Tolerance of apple and other raw rosacea re-consumption two months post- Ultra-Rush for patients treated between mid-April and mid-July, according to a Visual Analogue Scale (VAS) [[Time Frame: Day 1]]
7. Number of participants eating rosacea with no or mild OAS at 1 year [[Time Frame: Day 1]]
8. Biological sensitization profile of patients included [[Time Frame: Day 1]]