Aloe Vera Ointment Application and Skeletal Muscle Recovery
Palavras-chave
Resumo
Descrição
For the purpose of study, ten male participants will be included in a pilot clinical trial.
Initially, participants will undergo a baseline testing including assessment of body height, body mass and body composition, isokinetic evaluation of isometric, concentric and eccentric muscle strength of quadriceps, determination of VO2max, evaluation of DOMS level and resting blood sampling for the measurement of CK. Participants will be also provided with 7-day diet recalls and will be taught by a trained dietitian on how to adjust food/liquid portions and sizes and how to complete diet recalls (1 recall/day over a 7-day period).
After baseline testing, subjects will participate in two trials, in a randomized, double-blind repeated measures design. In the first trial they will execute a bilateral eccentric exercise protocol. Immediately after the exercise protocol and daily for 7 consecutive days, will be applied transdermal treatment with placebo (Control) in one leg and with natural aloe vera (Experimental, aloe vera peel and leaf) in the other. Following a 7-day wash-out period the second trial will be conducted. Participants will execute the same eccentric exercise protocol, but they will be treated with either placebo (Control) or aloe vera soup (Experimental). The selection of the treatment for each leg will be randomly selected. In both trials, assessment of DOMS and strength (isometric, concentric and eccentric) in both legs and blood sampling (for the measurement of CK) will be performed at 1h and 6h post-exercise as well as daily for 7 consecutive days.
datas
| Última verificação: | 03/31/2019 |
| Enviado pela primeira vez: | 04/25/2019 |
| Inscrição estimada enviada: | 04/29/2019 |
| Postado pela primeira vez: | 05/01/2019 |
| Última atualização enviada: | 12/29/2019 |
| Última atualização postada: | 01/01/2020 |
| Data real de início do estudo: | 04/24/2019 |
| Data Estimada de Conclusão Primária: | 05/14/2019 |
| Data Estimada de Conclusão do Estudo: | 05/29/2019 |
Condição ou doença
Intervenção / tratamento
Biological: Placebo
Biological: Natural aloe vera
Biological: Aloe vera soup
Fase
Grupos de Armas
| Braço | Intervenção / tratamento |
|---|---|
| Active Comparator: Placebo A placebo solution will be applied on the quadriceps of one of the lower limbs immediately after the exercise protocol and daily for 7 consecutive days. | Biological: Placebo A placebo solution that will not include aloe vera will be applied on the quadriceps of one of the lower limbs. |
| Experimental: Natural aloe vera A natural aloe vera solution (peel and leaf) will be applied on the quadriceps of one of the lower limbs immediately after the exercise protocol and daily for 7 consecutive days. | Biological: Natural aloe vera Natural aloe vera solution including peel and leaf from aloe will be applied on the the quadriceps of one of the lower limbs. |
| Experimental: Aloe vera soup An aloe vera soup solution will be applied on the quadriceps of one of the lower limbs immediately after the exercise protocol and daily for 7 consecutive days. | Biological: Aloe vera soup Aloe vera solution including aloe vera soup will be applied on the the quadriceps of one of the lower limbs. |
Critério de eleição
| Idades qualificadas para estudar | 18 Years Para 18 Years |
| Sexos elegíveis para estudo | Male |
| Aceita Voluntários Saudáveis | sim |
| Critério | Inclusion Criteria: - Absence of musculoskeletal injury for at least 6 months prior to the study. - No consumption of performance-enhancing supplements or medication for at least 6 months prior to the study. - No consumption of anti-inflammatory and antioxidant supplements for at least 6 months prior to the study. - No participation in exercise including eccentric muscle contractions for at least 3 days prior to the study. Exclusion Criteria: - Recent history of musculoskeletal injury. - Consumption of performance-enhancing supplements and medication. - Consumption of anti-inflammatory and antioxidant supplements (> 6 months). - Participation in exercise including eccentric muscle contractions during the last 3 days prior to the study. |
Resultado
Medidas de Resultado Primário
1. Change in creatine kinase activity in plasma [At baseline, 1 hour post-exercise, 6 hours post-exercise and daily for 7 consecutive days post-exercise]
2. Change in performance of knee extensor muscles [At baseline, 1 hour post-exercise, 6 hours post-exercise and daily for 7 consecutive days post-exercise]
3. Change in delayed onset of muscle soreness [At baseline, 1 hour post-exercise, 6 hours post-exercise and daily for 7 consecutive days post-exercise]
