Assessment of Venous Drainage in Idiopathic Intracranial Hypertension
Palavras-chave
Resumo
Descrição
The investigator working hypothesis is an impairment of the cerebral venous drainage in IIH compared to the circulation observed in healthy volunteers considered as the reference. The research will focus on adult patients referred to the imaging department for intracranial hypertension assessment. MRI support is common for this type of request The reference will be established in a population of healthy volunteers for whom MRI blood flow measurements will be performed. In addition to the primary objective, the investigators assess the impact of IIH on CSF dynamics The study does not present any risk for the subject, any contraindication to MRI examination being respected. The subjects will undergo MRI examination including morphological and flow sequences without contrast injection. The flow sequences, in planes located at the C2-C3 and aqueductal levels, will be used to measure vascular flows (venous and arterial) and CSF oscillatory volumes. Image post-processing will be performed on a semi-automatic software allowing to extract fluid dynamics parameters.
datas
Última verificação: | 01/31/2020 |
Enviado pela primeira vez: | 10/02/2019 |
Inscrição estimada enviada: | 10/02/2019 |
Postado pela primeira vez: | 10/03/2019 |
Última atualização enviada: | 02/24/2020 |
Última atualização postada: | 02/25/2020 |
Data real de início do estudo: | 02/18/2020 |
Data Estimada de Conclusão Primária: | 09/30/2022 |
Data Estimada de Conclusão do Estudo: | 09/30/2022 |
Condição ou doença
Intervenção / tratamento
Diagnostic Test: MRI examination
Diagnostic Test: ECG
Fase
Grupos de Armas
Braço | Intervenção / tratamento |
---|---|
Experimental: idiopathic intracranial hypertension patients with idiopathic intracranial hypertension | |
Sham Comparator: healthy subjects Healthy subjects |
Critério de eleição
Idades qualificadas para estudar | 18 Years Para 18 Years |
Sexos elegíveis para estudo | All |
Aceita Voluntários Saudáveis | sim |
Critério | Inclusion Criteria: - Age : >18 years old - adult patients referred to the imaging department for intracranial hypertension assessment - adult control subjects without history of cerebral or vascular pathology Exclusion Criteria: - history of cerebral or vascular pathology for the control subjects - pregnant woman - claustrophobia - major obesity - any contraindication to MRI exam |
Resultado
Medidas de Resultado Primário
1. Ratio between jugular vein flow and total arterial brain flow. [day 0 = day of inclusion]
Medidas de Resultado Secundário
1. CSF (cerebrospinal fluid) Stroke volumes [day 0 = day of inclusion]