Acanthopanax senticosus root inhibits mast cell-dependent anaphylaxis.
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Resumo
BACKGROUND
Mast cells synthesize and secrete chemical mediators which play a central role in anaphylaxis.
METHODS
The effect of Acanthopanax senticosus root (ASR) on mast cell-dependent anaphylaxis was investigated.
RESULTS
ASR inhibited compound 48/80-induced systemic anaphylactic shock at the dose of 1.0 g/kg by 50%. When ASR was given as pre-treatment at concentrations ranging from 0.01 to 2.0 g/l, the histamine release from rat peritoneal mast cells induced by compound 48/80 was reduced in a dose-dependent manner. ASR (2.0 g/kg) also inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE to 53.17+/-6.62%. Moreover, ASR inhibited tumor necrosis factor-alpha production in a concentration-dependent manner, and the treatment of 1 g/l blocked the production by 32.5+/-3.50% compared to saline value.
CONCLUSIONS
ASR may possess effective anti-anaphylactic activity.
