Biological effects study of Myricitrin and relevant molecular mechanisms.

In humans, oxidative stress is thought to be involved in the development of Parkinson' s disease, Alzheimer's disease, atherosclerosis, heart failure, myocardial infarction, depression. Myricitrin, a botanical flavone, is abundantly distributed in the root bark of Myrica cerifera, Myrica esculenta, Ampelopsis grossedentata, Nymphaea lotus, Chrysobalanus icaco, and other plants. Considering the abundance of its natural sources, myricitrin is relatively easy to extract and purify. Myricitrin reportedly possesses effective anti-oxidative, anti-inflammatory, and anti-nociceptive activities, and can protect a variety of cells from in vitro and in vivo injuries. Therefore, our current review summarizes the research progress of myricetin in cardiovascular diseases, nerve injury and anti-inflammatory, and provides new ideas for the development of myricitrin.