Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 2012-May
[Isolation and identification of brine shrimp lethal activities from Derris trifoliata].
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Resumo
OBJECTIVE
To study the brine shrimp lethal activities of the roots and stems from Derris trifoliata.
METHODS
The biological activity of the athyl acetate extract was tested by the 2nd-instar of Artemia franciscana by the method of Silica gel column chromatography, Sephadex LH-20 column chromatography, Semipreparative HPLC, and their structures were elucidated by spectral analysis.
RESULTS
Eleven compounds were isolated from the athyl acetate extract, and LD50 s of 12a-hydroxyrotenone, tephrosin, rotenone and deguelin were 0.365, 0.236, 0.060 and 0.734 microg/mL, respectively.
CONCLUSIONS
The results of bioassay show that 12a-hydroxyrotenone, tephrosin,rotenone and deguelin have strong brine shrimp lethal activity.
