Chemistry and Biodiversity 2020-Oct
Two New Isomeric Andrographolides with Anti-Inflammatory and Cytotoxic Activity
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Resumo
Two novel epimerized andrographolides, 8,17-dihydro-7,8-dehydroandrographolide and 10β-8,17-dihydro-7,8-dehydroandrographolide, were isolated from andrographolide sulfonates. Their structures were elucidated by detailed NMR analysis, single-crystal X-ray diffraction and quantum chemical ECD calculations. In addition, these compounds exhibited suppression of NO production in LPS-stimulated RAW264.7 cells over the range of 1.564 to 25.000 μg/mL.
Keywords: NO; derivatives; inflammation; isomeric andrographolide.
