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Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.

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OBJECTIVE To assess the therapeutic effect of melatonin on heat-induced acute lung inflammation and injury in rats. METHODS Heatstroke was induced by exposing anesthetized rats to heat stress (36 °C, 100 min). Rats were treated with vehicle or melatonin (0.2, 1, 5 mg/kg) by intravenous

Comparative study of different iron-chelating agents in cold-induced brain edema.

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Increasing numbers of reports demonstrate the importance of iron and oxygen free radicals in brain injury and brain edema. We investigated the protective effects of three different ferric and ferrous iron-chelating agents on cold-induced brain edema. Vasogenic brain edema was produced by a cortical

Interleukin-1 receptor antagonist restores homeostatic function and limits multiorgan damage in heatstroke.

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We attempt to investigate whether interleukin-1 receptor antagonist (IL-1ra) therapy improves survival during heatstroke by attenuating multiorgan dysfunction. Anesthetized rabbits, immediately after the onset of heatstroke, are divided into three major groups and given: nothing, normal saline (1

Polyphenol compounds and anti-inflammatory activities of Korean black raspberry ( Rubus coreanus Miquel) wines produced from juice supplemented with pulp and seed.

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Three types of Korean black raspberry wine were produced via alcoholic fermentation from juice, juice-pulp, and juice-pulp-seed, respectively. These wines were compared in terms of their anti-inflammatory activities and polyphenol contents. The total content of polyphenol compounds in wines was

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