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Chronic colchicine treatment does not impair glucose tolerance in familial Mediterranean fever patients.

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OBJECTIVE To investigate a long-term colchicine treatment in inhibiting normal release of insulin, in response to a glucose load. METHODS The Heller Institute of Medical Research, Sheba Medical Center, Tel-Hashomer. METHODS Thirty-one familial Mediterranean fever (FMF) patients, treated continuously

Aspects of biochemical effects by hyperthermia.

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Hyperthermia caused an immediate decrease of DNA, RNA, and protein synthesis. The latter process was most sensitive. Initiation of DNA synthesis at the transition from G1-to S-phase and at the start of new replication units were inhibited. These effects were responsible for the growth delay of cells

Haemolysis with Mediterranean spotted fever and glucose-6-phosphate dehydrogenase deficiency.

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Mediterranean spotted fever with haemolysis is reported in a glucose-6-phosphate dehydrogenase deficient Algerian man. The clinical course was unusually severe for a 27-year-old patient. The authors suspect G6PD deficiency to be a cause of enhanced severity in Mediterranean spotted fever as well as

Failure of preventive effects of 2-deoxy-D-glucose on ischemia-induced gerbil hippocampal neuronal damage by induced hyperthermia.

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Post-ischemic administration of 2-deoxy-D-glucose (2-DG), a glucose antimetabolite, markedly reduces the occurrence of ischemia-induced delayed neuronal death (DND) in the gerbil hippocampus. This means that the reduction of energy dependent metabolism after ischemia prevents ischemia-induced

Outcomes after environmental hyperthermia.

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OBJECTIVE This study was conducted to describe the characteristics and outcomes of patients who presented to the emergency department (ED) with presumed environmental hyperthermia. METHODS A retrospective chart review was performed in 2 institutions with patients who were seen in the ED and had a

Effect of natriuretic peptide receptor antagonist on lipopolysaccharide-induced fever in rats: is natriuretic peptide an endogenous antipyretic?

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We investigated whether natriuretic peptide (NP) acts as an endogenous antipyretic inside and/or outside the blood-brain barrier in rats made febrile by systemic administration of bacterial endotoxin (lipopolysaccharide; LPS). Intravenous (i.v.) injection of LPS induced a triphasic fever, the second

The effect of bleomycin administered in combination with hyperthermia on a C3H mouse fibrosarcoma.

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The effect of bleomycin (BLM) on a murine fibrosarcoma, FSa-II, was investigated at elevated temperatures. Animals were C3Hf/Sed mice derived from our defined flora mouse colony. Single-cell suspensions of the tumour were transplanted into the murine foot. Tumours with an average diameter of 4 mm

Effect of glucose infusion on the concentration of individual serum free amino acids during sandfly fever in man.

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After an intravenous glucose load in man, total serum amino acid concentrations are rapidly depressed and remain below baseline values for at least 2 to 3 hr after serum glucose and insulin have returned to preload concentrations. Despite the presence of basal hypoaminoacidemia, a decreased glucose

Synergism between alkylating agent and cis-platin with moderate local hyperthermia: the effect of multidrug chemotherapy in an animal system.

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The combined effect of multidrug chemotherapy given in combination with hyperthermia was investigated using early-generation isotransplants of a spontaneous fibrosarcoma, FSa-II in C3Hf/Sed mice. Combinations of various types of chemotherapeutic agents, including alkylating agents, cyclophosphamide

Hyperthermia impairs liver mitochondrial function in vitro.

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The effects of temperature on the relationships among the rates of pyruvate carboxylation, O(2) uptake (J(o)), oxidative phosphorylation (J(p)), and the free energy of ATP hydrolysis (G(p)) were studied in liver mitochondria isolated from 250-g female rats. Pyruvate carboxylation was evaluated at

[Medium-chain acyl-CoA dehydrogenase deficiency: contribution of molecular biology].

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BACKGROUND Medium-chain acyl-CoA dehydrogenase deficiency is the most frequent cause of defective congenital fatty acid oxidation. Its molecular characterization is now possible. Case n. 1. A girl, 15 month-old, was admitted because she suffered from fever and vomiting, requiring the administration

Multi-sulfonated ligands on gold nanoparticles as virucidal antiviral for Dengue virus

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Dengue virus (DENV) causes 390 million infections per year. Infections can be asymptomatic or range from mild fever to severe haemorrhagic fever and shock syndrome. Currently, no effective antivirals or safe universal vaccine is available. In the present work we tested different gold nanoparticles

Enterococcal meningitis caused by Enterococcus casseliflavus. First case report.

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BACKGROUND Enterococcal meningitis is an uncommon disease usually caused by Enterococcus faecalis and Enterococcus faecium and is associated with a high mortality rate. Enterococcus casseliflavus has been implicated in a wide variety of infections in humans, but never in meningitis. METHODS A

Acute renal failure after large doses of intravenous immune globulin.

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OBJECTIVE To describe a case of acute renal failure after high-dose intravenous immune globulin (IVIG) therapy and the measures undertaken to prevent this complication during subsequent administration. METHODS A 54-year-old white man with valvular cardiomyopathy was receiving large doses (2 g/kg/mo)

[Intramedullary tuberculoma: a case report].

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A fifty-year-old Portuguese man presented with a six-month history of low back pain, which initially was mechanical and slowly became inflammatory. Secondarily, he complained of right atypical sciatalgia. He did not report any fever, loss of weight, cough nor personal or familial history of

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