A composition in the form of a biodegradable gel, chip or ointment is provided, for adjunct treatment of periodontitis, comprising: (i) an antimicrobial extract having antimicrobial or antibacterial activity against periodontal pathogens, preferably from one or more of the plants Andrographis paniculata, mangosteen (Garcinia mangostana) and turmeric (Curcuma longa); and (ii) a gel base containing a mixture of glyceryl monooleate and triglyceride. The composition is biodegradable, and forms a liquid crystal structure on contacting gingival fluid, which liquid crystal structure releases active ingredients gradually, to provide a sustained release dosage form.

Mahidol University

andrographis echioides/bactericida

Andrographis paniculata gel as an adjunct in the treatment of periodontitis

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