antiasthmatic/cancro

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Anti-asthmatic effect of schizandrin on OVA-induced airway inflammation in a murine asthma model.

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Asthma comprises a triad of reversible airway obstruction, bronchial smooth muscle cell hyperreactivity to bronchoconstrictors, and chronic bronchial inflammation. Clinical and experimental findings have established eosinophilia as a sign of allergic disorders. In the present investigation, we

[Endotracheal neoplasm of a 16-year-old boy: Extremely rare primary localisation of a B-cell non-Hodgkin's lymphoma].

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Primary neoplasms of the trachea are rare, in contrast to the larynx and the bronchial tree. Most common types of secondary tracheal tumors are infiltrating esophageal and thyroid cancers, or infiltrating lymph node metastasis. Systemic non-Hodgkin's lymphomas may also involve the upper airway. Here

Anti-asthmatic effects of volatile organic compounds from Chamaecyparis obtusa, Pinus densiflora, Pinus koraiensis, or Larix kaempferi wood panels.

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Asthma is a common chronic inflammatory disease in which lung airways narrow and produce extra mucus. Numerous medications, such as steroids, are used to prevent or control asthmatic symptoms, but side effects are associated with those medications. There are reports of anti-inflammatory,

An aqueous extract of green tea Camellia sinensis increases expression of Th1 cell-specific anti-asthmatic markers.

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The present study provides evidence of the anti-asthmatic signaling activity of an aqueous fraction of green tea using specific in vitro and in vivo assays in an ovalbumin-induced asthmatic model. Mice sensitized to ovalbumin were orally administered an aqueous extract of Camellia sinensis. The

Antiasthmatic activity of quercetin glycosides in neonatal asthmatic rats.

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The present study investigated the anti-asthmatic activity of quercetin glycosides in neonatal asthmatic rats. Rats were divided into four groups: sham (non-asthmatic), asthmatic control, quercetin (25 mg/kg), and quercetin (50 mg/kg). Inflammatory cells in bronchoalveolar lavage fluid (BALF),

The evaluation of antioxidant and anticancer effects of Lepidium Sativum Subsp Spinescens L. methanol extract on cancer cells.

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In recent years, there is an increased research interest for plants which are natural sources of antioxidants. Lepidium sativum Subsp spinescens L., commonly found in South West Asia, is a plant known as a healthy nutritional source containing bio-molecules that carry anti-hypertensive,

Chemopreventive effects of Ginkgo biloba extract in estrogen-negative human breast cancer cells.

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Excessive level of estrogen is considered as a main cause of breast cancer, therefore, many studies have focused on estrogen receptor (ER)-positive breast cancer, even though ER-negative cancer has a poor prognosis than ER-positive breast cancer. We evaluated the anti-cancer effects of Ginkgo biloba

The Ethanol Extract of Holotrichia diomphalia Larvae, Containing Fatty acids and Amino acids, Exerts Anti-Asthmatic Effects through Inhibition of the GATA-3/Th2 Signaling Pathway in Asthmatic Mice.

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Holotrichia diomphalia larvae (HD), a natural product from an insect resource, possesses many pharmacological properties, including anticoagulant, antitumor, anti-inflammatory, and analgesic activity. The major bioactive ingredients include oleic acid, palmitic acid, palmitoleic acid,

Investigation of the anti‑asthmatic activity of Oridonin on a mouse model of asthma.

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Oridonin is an extract obtained from a traditional Chinese medicinal herb, Xihuangcao. Previous studies have demonstrated that Oridonin exerts various pharmaceutical effects, such as anti‑tumor and immunosuppressive effects, as well as modulating cytokine balance. The present study identified that

The cytotoxic effect of oxymatrine on basic cellular processes of A549 non-small lung cancer cells.

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Oxymatrine is the alkaloid derived from the root of Sophora species. This compound is proven to exhibit anti-viral, anti-asthmatic, anti-fibrotic and anti-inflammatory properties. Additionally, oxymatrine is able to promote cancer cells apoptosis and inhibit their proliferation. The aim of this

Discovery of the inhibitors of tumor necrosis factor alpha with structure-based virtual screening.

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Tumor necrosis factor alpha (TNF-α) has been considered as one of the attractive drug targets for allergic diseases including asthma. We have been able to identify five novel TNF-α inhibitors with a drug-design protocol involving the structure-based virtual screening and in vitro cell-based assay

Cancer Chemoprevention and Piperine: Molecular Mechanisms and Therapeutic Opportunities.

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Cancer is a genetic disease characterized by unregulated growth and dissemination of malignantly transformed neoplastic cells. The process of cancer development goes through several stages of biochemical and genetic alterations in a target cell. Several dietary alkaloids have been found to inhibit

The synergistic anti-asthmatic effects of glycyrrhizin and salbutamol.

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OBJECTIVE To investigate the efficacy of glycyrrhizin (GL) combined with salbutamol (SA) as an anti-asthma therapy. METHODS Rat lung beta2-adrenergic receptor (beta(2)-AR) mRNA level was measured by real-time RT PCR. Intracellular cAMP accumulation was evaluated with a reporter gene assay. An in

Collagen Prolyl Hydroxylation-Dependent Metabolic Perturbation Governs Epigenetic Remodeling and Mesenchymal Transition in Pluripotent and Cancer Cells.

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Collagen prolyl hydroxylation (CPH), which is catalyzed by prolyl 4-hydroxylase (P4H), is the most prevalent posttranslational modification in humans and requires vitamin C (VitC). Here, we demonstrate that CPH acts as an epigenetic modulator of cell plasticity. Increased CPH induced global

Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs.

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The G protein-coupled cysteinyl leukotriene receptor CysLT₁R mediates inflammatory processes and plays a major role in numerous disorders, including asthma, allergic rhinitis, cardiovascular disease, and cancer. Selective CysLT₁R antagonists are widely prescribed as

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