anxiolytic/acidente vascular cerebral

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Neuroprotective 3-(piperidinyl-1)-chroman-4,7-diol and 1-(4-hydroxyphenyl)-2-(piperidinyl-1)-alkanol derivatives

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BACKGROUND OF THE INVENTION The present invention is directed to neuroprotective (antiischemic and excitatory aminoacid receptor blocking) phenol derivatives defined by the formula (I) below; pharmaceutically acceptable salts thereof; pharmaceutical compositions thereof; a method of using these

N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-HT4 receptor antagonists

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This application is a 371 of PCT/GB93/02130, Oct. 14, 1993. This invention relates to novel compounds having pharmacological activity, to a process for their preparation and to their use as pharmaceuticals. European Journal of Pharmacology 146 (1988 ), 187-188, and Naunyn-Schmiedeberg's Arch.

Method for treating spinal cord trauma with phenolic 2-piperidino-1-alkanols

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BACKGROUND OF THE INVENTION The present invention is directed to prodrug esters of phenolic 2-piperidino-1-alkanols, as depicted by the formulas (I) and (II), below; to pharmaceutical compositions thereof; to a method of treating stroke, traumatic head injury, or a CNS degenerative disease

2-piperidino-1-alkanol derivatives as neuroprotective agents

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BACKGROUND OF THE INVENTION The present invention is directed to neuroprotective (antiischemic and excitory aminoacid receptor blocking) 2-piperidino-1-alkanol derivatives defined by the formula (I) below; pharmaceutically acceptable salts thereof; a method of using these compounds in the treatment

Quinolinic sulfide derivatives acting as NMDA receptor antagonists and process for preparation thereof

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FIELD OF THE INVENTION The present invention relates to therapeutically active quinolinic sulfide derivatives acting as potent and specific antagonists of excitatory amino acids, to a process for preparation and to their use in treatment in neurological disorders. Particularly, the compounds

NMDA receptor agonist pharmaceutical compositions

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BACKGROUND OF THE INVENTION This invention provides stable pharmaceutical compositions of the N-methyl-D-aspartic acid (NMDA) receptor antagonist, (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propano l, methods of preparing such pharmaceutical compositions and methods of

Neuroprotective indolone and related derivatives

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BACKGROUND OF THE INVENTION The present invention is directed to a method of blocking N-methyI-D-aspartic (NMDA) acid receptor sites in a mammal in need thereof with an effective NMDA blocking (neuroprotective and antiischemic) amount of 5-(1-hydroxy-2-piperidino)-propyl-2(1H,3H)-indolone analogs,

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