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bulleyaconitine a/aconitum bulleyanum
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6 resultados
Studies on metabolites and metabolic pathways of bulleyaconitine A in rat liver microsomes using LC-MS(n) combined with specific inhibitors.
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Bulleyaconitine A (BLA) from Aconitum bulleyanum plants is usually used as anti-inflammatory drug in some Asian countries. It has a variety of bioactivities, and at the same time some toxicities. Since the bioactivities and toxicities of BLA are closely related to its metabolism, the metabolites and
Bulleyaconitine A Inhibits Visceral Nociception and Spinal Synaptic Plasticity through Stimulation of Microglial Release of Dynorphin A
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Background: Visceral pain is one of the most common types of pain and particularly in the abdomen is associated with gastrointestinal diseases. Bulleyaconitine A (BAA), isolated from Aconitum bulleyanum, is prescribed in China to
Bulleyaconitine A attenuates hyperexcitability of dorsal root ganglion neurons induced by spared nerve injury: The role of preferably blocking Nav1.7 and Nav1.3 channels.
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Background Oral administration of Bulleyaconitine A, an extracted diterpenoid alkaloid from Aconitum bulleyanum plants, is effective for treating chronic pain in rats and in human patients, but the underlying mechanisms are poorly understood. Results As the hyperexcitability of dorsal root ganglion
[Chemical constituents of Aconitum bulleyanum].
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OBJECTIVE
To study the chemical constituents of chloroform fraction from Aconitum bulleyanum.
METHODS
The compounds were isolated by various chromatographic techniques and identified by spectroscopic methods.
RESULTS
7 compounds were obtained and identified as yunaconitine (1), crassicaudine (2),
Mechanisms for therapeutic effect of bulleyaconitine A on chronic pain.
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Bulleyaconitine A, a diterpenoid alkaloid isolated from Aconitum bulleyanum plants, has been used for the treatment of chronic pain in China since 1985. Clinical studies show that the oral administration of bulleyaconitine A is effective for treating different kinds of chronic pain, including back
Bulleyaconitine A isolated from aconitum plant displays long-acting local anesthetic properties in vitro and in vivo.
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BACKGROUND
Bulleyaconitine A (BLA) is an active ingredient of Aconitum bulleyanum plants. BLA has been approved for the treatment of chronic pain and rheumatoid arthritis in China, but its underlying mechanism remains unclear.
METHODS
The authors examined (1) the effects of BLA on neuronal
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