A 2-phenylpiperazine derivative represented by the formula (I) or a pharmaceutically acceptable salt, hydrate, or complex thereof: ##STR1##wherein each of X.sub.1 and X.sub.3 is oxygen or two hydrogen atoms, X.sub.2 O, NH, NCH.sub.3, or CH.sub.2, n is an integer of 0 or 1, R.sub.1 is hydrogen or lower alkyl and R.sub.2 is hydrogen, cyano, tetrazolyl, aminotriazolyl , mesyl, t-butoxycarbonyl, or a lower alkyl which may be optionally substituted, R.sub.3 is hydrogen, halogen, lower alkyl or lower alkoxy, each of R.sub.4 and R.sub.5 is hydrogen, lower alkoxy or trifluoromethyl, and a broken line indicates a single or double bond. The derivative may be used as a tachykinin antagonist in the treatment of diseases of the digestive system, nervous system and respiratory system, inflammation, allergy, carcinoid syndrome, chronic pain, headache, Crohn disease, depression and vomiting.

carcinoid tumor/vômito

2-phenylpiperazine derivatives

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