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Prophylaxis with carnosol attenuates liver injury induced by intestinal ischemia/reperfusion.
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OBJECTIVE
To investigate the possible protective effects of carnosol on liver injury induced by intestinal ischemia reperfusion (I/R).
METHODS
Rats were divided randomly into three experimental groups: sham, intestinal I/R and carnosol treatment (n = 18 each). The intestinal I/R model was
Protective effect of carnosol on lung injury induced by intestinal ischemia/reperfusion.
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OBJECTIVE
Carnosol is a phenolic diterpene that has potent antioxidant and anti-inflammatory activities. The purpose of this study was to investigate the preconditioning effects of carnosol on lung injury induced by intestinal ischemia/reperfusion (II/R).
METHODS
Rats were divided into control,
Carnosol suppresses interleukin-6 production in mouse lungs injured by ischemia-reperfusion operation and in RAW264.7 macrophages treated with lipopolysaccharide.
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Carnosol is a naturally occurring herbal compound, known for its antioxidative properties. We previously found that carnosol protected mouse lungs from ischemia-reperfusion injury in ex vivo cultures. To elucidate the molecular mechanisms underpinning carnosol-mediated lung protection, we analyzed
Carnosol protects against renal ischemia-reperfusion injury in rats.
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Acute kidney injury, which is caused by renal ischemia-reperfusion injury (IRI), occurs in several clinical situations and causes severe renal damage. There is no effective therapeutic agent available for renal IRI at present. In this study, we performed an experiment based on an in vivo murine
Carnosol Is a Potent Lung Protective Agent: Experimental Study on Mice.
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BACKGROUND
Oxidative stress has been implicated in various disease states and ischemia/reperfusion injury is a direct consequence of oxidative stress in lung transplantation. Because the success rate of organ transplantation in which ischemia/reperfusion is inevitable is highly influenced by
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