In the levosimendan group, levosimendan will be used in addition to standard inotropic therapy (one or more agent including; dopamine, dobutamine, noradrenaline, adrenaline)for 24 hours.Levosimendan dosage; a loading dose of levosimendan (6 μg kg-1) will be administered after removal of the aortic cross-clamp, followed by an infusion of levosimendan at a dose of 0.1 μg kg-1 min-1.

In the control group, only standard inotropic therapy (one or more agent including; dopamine, dobutamine, noradrenaline, adrenaline)will be administered

Mitral Valve Stenosis With Incompetence or Regurgitation

The effects of levosimendan on renal function

Levosimendan

Dobutamine

Kartal Kosuyolu High Speciality Training and Research Hospital

The Effects of Levosimendan During Mitral Valve Surgery

The Effects of Levosimendan on Renal Function in Patients With Low Ejection Fraction Undergoing Mitral Valve Surgery.

The effects of levosimendan on postoperative renal function measured by serum creatinine (sCr) levels and estimated glomerular filtration rate (eGFR).

Secondary end points were the effects of levosimendan on clinical outcomes which include the pre- and perioperative prognostic risk factors such as; 1-aortic cross-clamp time, 2- cardiopulmonary bypass time, 3- the use of inotropic support, 4-intra-aortic balloon pump, 5- prolonged mechanical ventilation, 6-development of pneumonia, 7- Perioperative myocardial infarction, 8- cerebrovascular event (stroke, transient ischemic attack), 9- atrial fibrillation and other rhythm disturbances, 10- need for renal replacement therapy (RRT), 11-reoperation secondary to bleeding, 12-intensive care unit stay and 13- hospital stay.

Hemodynamic measurements include;
1- Cardiac output, 2-cardiac index (CI), 3-mean arterial pressure (MAP), 4-heart rate (HR), were recorded just before the start of surgery, at the end of CPB, on admission to the ICU, and postoperatively at 6 and 24 h later in the ICU. Hemodynamic targets were as follows: MAP ≥70 mmHg, CI ≥ 2.0 L/min/m2 without signs of poor peripheral perfusion (oliguria, acidosis).

Ayse Baysal

Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital

12 weeks ambulatory low level exercise training

Heart Defects, Congenital

12 weeks low level ambulatory structured exercise training

Structured exercise training

Virgen Macarena University Hospital

University Hospital Basel

Inselspital Bern

University Hospital Zurich

Rehabilitation in Patients With Congenital Heart Disease

Cardiac Rehabilitation in Patients With Complex Congenital Heart Disease: Improvement of Exercise Intolerance

Comparison between groups and within groups

Difference between peak heart rate and resting heart rate Comparison between groups and within groups

Comparison between groups and within groups Minnesota Heart failure Score and SF 36

endocarditis/potássio

The Effects of Levosimendan During Mitral Valve Surgery

Rehabilitation in Patients With Congenital Heart Disease

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