Diet and Water Adjustment

Control

Total

Sex: Female, Male

Region of Enrollment

The copeptin level will reflect the combined effect of low osmolar diet and adjusted water intake at week 2

Change in Mean Serum Copeptin From Baseline (a Reflection of Endogenous Vasopressin Production) at Week 2

Total daily urinary solutes (this will serve as a surrogate for diet adherence and is known to be associated with lower vasopressin secretion).
Total daily solutes is the total amount of osmoles detected in 24 hours urine collection.

Change in Total Daily Urinary Solutes From Baseline to Week 2

Mean serum copeptin level at week one which will reflect the effect of low osmolar diet alone.

Reduction in dietary salt and protein intake
Diet and water adjustment: The dietary intervention consisted of three elements: low sodium (1500 mg/day), low protein (daily protein dietary allowance of 0.8 gram/kg body weight), and low urea (avoidance of preservatives, food additives, bulking agents, and chewing gum). Protein was factored by measured body weight to mirror the estimated average requirement (EAR) of healthy adults which is set on a grams per kilogram basis

Change in Mean Serum Copeptin Level From Baseline to Week 1

Overall Study

Ronald D. Perrone

Autosomal Dominant Polycystic Kidney Disease (ADPKD)

The dietary intervention consisted of three elements: low sodium (1500 mg/day), low protein (daily protein dietary allowance of 0.8 gram/kg body weight), and low urea (avoidance of preservatives, food additives, bulking agents, and chewing gum). Protein was factored by measured body weight to mirror the estimated average requirement (EAR) of healthy adults which is set on a grams per kilogram basis

hypernatremia/arginina

Diet as a Potential Treatment for Autosomal Dominant Polycystic Kidney Disease

O mais completo banco de dados de ervas medicinais apoiado pela ciência