hypothermia/cancro

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Fever-range hyperthermia vs. hypothermia effect on cancer cell viability, proliferation and HSP90 expression.

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OBJECTIVE The current study examines the effect of fever-range hyperthermia and mild hypothermia on human cancer cells focusing on cell viability, proliferation and HSP90 expression. METHODS A549 and H1299 lung carcinoma, MCF7 breast adenocarcinoma, U87MG and T98G glioblastoma, DU145 and PC3

Use of combined systemic hypothermia and local heat treatment to enhance temperature differences between tumor and normal tissues.

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The feasibility of combining local heat treatment with whole-body hypothermia in an effort to improve therapeutic gain was assessed. Superficial, nonperfused phantom tumors were fashioned in eight anesthetized mongrel dogs by transplantation of the spleen from the abdomen to a subcutaneous site on

Surgical management of retroperitoneal tumors with vena caval thrombus in the inferior cava using cardiopulmonary bypass, arrested circulation and profound hypothermia.

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OBJECTIVE It was our aim to review our surgical experience with retroperitoneal tumors extending to the vena cava by using cardiopulmonary bypass, deep hypothermia and circulatory arrest. METHODS We performed this procedure in 15 patients. The ages ranged between 16 and 70 years. The primary

[Neoplastic caval and intracardiac thrombosis secondary to reno-adrenal tumors. One-stage surgical treatment in deep hypothermia and cardiocirculatory arrest].

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Due to the considerable progress made by instrumental total body diagnostics (ECO, CAT, RMN, angiography, etc.) in recent years heart surgery has increasingly often been used to treat pathologies which are not primarily cardiac but which see the involvement of the heart and large vessels in the

[Treatment of renal cancer extending supradiaphragmatically with fibrinolytics following surgery under extracorporeal circulation, hypothermia and circulatory arrest].

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The authors report a case of right renal carcinoma with a supradiaphragmatic vena cava thrombus. The patient presented to the emergency ward with a severe pulmonary embolus managed by fibrinolytic treatment. After alcohol embolization of the tumor, the patient underwent a right radical nephrectomy

Perioperative hypothermia does not enhance the risk of cancer dissemination.

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BACKGROUND Resistance to cancer metastasis is mediated by host immunity, and mild perioperative hypothermia impairs immune function. We tested the hypothesis that mild perioperative hypothermia increases the risk of cancer recurrence and subsequent mortality METHODS In a 5- to 9-year follow-up of

Deep hypothermia and low flow for surgery for abdominal or extraperitoneal tumors with cavoatrial extension.

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BACKGROUND Surgical treatment of retroperitoneal tumors with cavoatrial involvement can be challenging. Completeness of resection of the cava tumor extension is crucial for the patient's survival. We report a monocentric experience with the use of cardiopulmonary bypass and deep hypothermic low flow

[Cardiopulmonary by-pass with cardiac arrest and deep hypothermia for the surgical treatment of tumor thrombi in the vena cava caused by kidney carcinoma].

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The by-pass technique with controlled cardiac arrest and hypothermia is probably the best method for an extirpation of intracava tumoral thrombi in renal tumours. The technique is easy to perform, represents a great help in the extirpation of thrombi regardless their size and location, and avoids

Extensive tumor resection under deep hypothermia and circulatory arrest.

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The risk of fatal hemorrhage may limit the completeness of resection in hepatic malignancies and in vascular extensions of Wilms' tumors. We have used Ein's technique of deep hypothermia (average 17 degrees C) with cardiac arrest (average 39 minutes) and exsanguination in performing five hepatic and

Circulating tumor necrosis factor-alpha does not mediate endotoxin-induced hypothermia in rats.

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The present study was designed to investigate the role of macrophages and circulating tumor necrosis factor-alpha (TNF-alpha) in the endotoxin-induced hypothermic responses in rats. Intravenous as well as intraperitoneal administration of endotoxin to male Wistar rats (0.5 mg/kg) led to increased

Intraperitoneal hypothermia during surgery enhances postoperative tumor growth.

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BACKGROUND Recent work has shown that intraoperative hypothermia is a significant source of surgical trauma, with wide-ranging physiological and immunological sequelae. The aim of this study was to examine the effects of intraperitoneal hypothermia during laparoscopy on tumor growth in an animal

Moderate hypothermia for intradural spinal tumor resection: a cohort comparison and feasibility study.

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To evaluate the safety and feasibility of modest hypothermia as a potential strategy for intraoperative neuroprotection during the removal of intradural spinal tumors. A retrospective review was performed for two groups of patients of a single surgeon who underwent intradural extrameduallary and

Hypothermia in barbiturate-anesthetized rats suppresses natural killer cell activity and compromises resistance to tumor metastasis: a role for adrenergic mechanisms.

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BACKGROUND Clinical studies have implicated surgery in promoting infections and compromising immune functions, including natural killer cell activity. Animal studies indicate that surgery-induced suppression of natural killer cell activity also promotes tumor metastasis. Hypothermia, a common

[Total and cranio-cerebral hypothermia in patients subjected to surgery for brain tumors].

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The paper is based on the authors' personal experience in the employment of general and craniocerebral hypothermia in 90 patients operated on for brain tumours. The most rational level of hypothermia is that of 30-31 degrees C body temperature. Craniocerebral hypothermia induced by the "Holod-2F"

Hypothermia activates adipose tissue to promote malignant lung cancer progression.

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Microenvironment has been increasingly recognized as a critical regulator of cancer progression. In this study, we identified early changes in the microenvironment that contribute to malignant progression. Exposure of human bronchial epithelial cells (BEAS-2B) to methylnitrosourea (MNU) caused a

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