The present invention relates to novel synthetic analogs of phosphatidyl-myo-inositol mannosides (hereinafter referred to as PIMs) of general formula (I): or a pharmaceutically acceptable salt thereof, to the method for preparing same and to the use thereof in the prevention or treatment of a disease associated with the overexpression of cytokines or of chemokines, in particular of TNF and/or of IL-12. The invention also relates to a pharmaceutical composition comprising at least one synthetic derivative of PIM. ##STR00001##

Quesniaux Ryffel; Valerie

Martin; Olivier

Front; Sophie

Centre National de la Recherche Scientifique--CNRS--

Universite d'Orleans

Synthetic analogues of phosphatidyl-myo-inositol mannosides with an inhibitory activity of the inflammatory response

D-mannoside-6-phosphate compounds having anti-inflammatory activity are disclosed, and use thereof in treating inflammatory diseases, particularly cell-mediated inflammatory diseases.

Australian National University

Phosphosugars and phosphosugar-containing compounds having anti-inflammatory activity

An antagonist of the interaction between the Gp96 receptor and E. coli AIEC strains, for the prevention or treatment of inflammatory bowel disease. The antagonist is for specifically blocking or reducing the interaction between Gp96 receptor and the outer membrane vesicles (OMVs), typically the outer protein membrane OmpA of E. coli AIEC strains. The inventions provides for pharmaceutical compositions containing such an antagonist, which may be an antibody against gp96 or OmpA, or a gp96 or OmpA polypeptide. It may be combined to an antagonist of the interaction between the CEACAM6 receptor and E. coli AIEC strains, such as an anti-CEACAM6 antibody, a CEACAM6 polypeptide, or a mannoside or particle having a mannose unit. The invention also relates to a method for the diagnosis of inflammatory bowel disease, or of the determination of a predisposition of a person to develop inflammatory bowel disease.

Darfeuille-Michaud; Arlette

Hofman; Paul

Rolhion; Nathalie

Universite d'Auvergne Clermont I

Antagonists for the prevention or treatment of inflammatory bowel disease, and more particularly of Crohn's disease

mannoside

inflamação

inflammation

mannoside/inflamação

Synthetic analogues of phosphatidyl-myo-inositol mannosides with an inhibitory activity of the inflammatory response

Phosphosugars and phosphosugar-containing compounds having anti-inflammatory activity

Antagonists for the prevention or treatment of inflammatory bowel disease, and more particularly of Crohn's disease

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