This arm will receive the Scrambler intervention for 1 hour daily x10 days.

This arm will receive the Sham-Control intervention for 1 hour daily x10 days.

This arm will receive the Scrambler intervention for 1 hour daily x10 days.
Scrambler: Scrambler is a non-invasive pain modifying technique that utilizes transcutaneous electrical stimulation of nociceptive fibers with the intent of re-organizing maladaptive signaling pathways which has been investigated for treatment of peripheral neuropathy.

Scrambler

This arm will receive the Sham-Control intervention for 1 hour daily x10 days.
Scrambler Sham Control: Sham control should be indistinguishable to the participants from experimental Scrambler therapy.

Sham-Control

Total

Sex: Female, Male

Race (NIH/OMB)

Aquaporin-4 Antibody Seropositive

Will be determined by how many participants say "yes" to the following question, "Would you want to continue the treatment if it were available?"

Acceptability as Assessed by the Number of Participants Responding Yes to a Question

Adherence to visit schedule will be determined by the number of participants that completed the 10 treatment visits.

Feasibility as Assessed by Number of Participants That Completed Treatment Visits

Change in NRS pain score (score ranges from 1 to 10 with 1 being "No pain" and 10 being "Worst pain") will be calculated by subtracting the patient's Day 10 pain score (end of treatment) from his or her baseline value.

Median NRS scores prior to receiving 10-day treatment course

Scrambler Pre

Median NRS scores directly following 10-day treatment course to receiving treatment

Scrambler Post

Median NRS scores prior to receiving 10-day sham

Sham Pre

Median NRS scores directly following 10-day sham

Sham Post

Change in Pain Level

Scrambler 30-day Post

Sham 30-day Post

Scrambler 60-day Post

Sham 60-day Post

Overall Study

Dr. Michael Levy

Neuromyelitis Optica

Scrambler is a non-invasive pain modifying technique that utilizes transcutaneous electrical stimulation of nociceptive fibers with the intent of re-organizing maladaptive signaling pathways which has been investigated for treatment of peripheral neuropathy.

Sham control should be indistinguishable to the participants from experimental Scrambler therapy.

Scrambler Sham Control

Johns Hopkins University

Scrambler Trial for Pain in NMOSD

Phase II, Randomized, Single Blind Sham Controlled Trial Investigating Scrambler Therapy for Neuropathic Pain Caused by Neuromyelitis Optica Spectrum Disorder

Autologous hematopoietic stem cell transplantation will be performed after conditioning regimen of cyclophosphamide 200 mg/kg/intravenously(IV), rATG(thymoglobulin) 5.5 mg/kg/IV and rituximab 1000mg/IV.

Hematopoietic Stem Cell Transplantation for CIDP

Region of Enrollment

Survival of participants who survived the treatment and up to 5 years post treatment.

Autologous hematopoietic stem cell transplantation will be performed after conditioning regimen of cyclophosphamide 200 mg/kg/intravenously(IV), rATG(thymoglobulin) 5.5 mg/kg/IV and rituximab 1000mg/IV

Number of Participants With Survival

Post transplant immune medication-free remission with stable or improving neurological exam

Disease Improvement - Medication Free Remission

Disease Improvement - Requires No Assistance to Ambulate

Disease Improvement - Ambulatory Assistance

Change in the Medical Research Council (MRC) Scale: range is 0 (quadriplegic) - 60 (normal).

Change in Disability and Strength Functional Scales

Hematopoietic Stem Cell Transplantation

Kathleen Quigley

Chronic Inflammatory Demyelinating Polyneuropathy

Autologous hematopoietic stem cell transplantation

hematopoietic stem cell transplantation

Hematopoietic Stem Cell Transplantation for Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Northwestern University, Feinberg School of Medicine

Hematopoietic Stem Cell Transplantation in Chronic Inflammatory Demyelinating Polyneuropathy

Non-myeloablative Autologous Hematopoietic Stem Cell Transplantation in Patients With Chronic Inflammatory Demyelinating Polyneuropathy: A Phase II Trial

neuromyelitis optica/fadiga

Scrambler Trial for Pain in NMOSD

Hematopoietic Stem Cell Transplantation in Chronic Inflammatory Demyelinating Polyneuropathy

O mais completo banco de dados de ervas medicinais apoiado pela ciência