osteolysis/obesidade

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Obesity/type 2 diabetes increases inflammation, periosteal reactive bone formation, and osteolysis during Staphylococcus aureus implant-associated bone infection.

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Obese and type 2 diabetic (T2D) patients have a fivefold increased rate of infection following placement of an indwelling orthopaedic device. Though implant infections are associated with inflammation, periosteal reactive bone formation, and osteolysis, the effect of obesity/T2D on these

Influence of obesity on femoral osteolysis five and ten years following total hip arthroplasty.

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BACKGROUND The most important long-term complication following total hip arthroplasty is periprosthetic femoral osteolysis. A sizeable proportion of patients who undergo arthroplasty are obese. While patient activity, implant type, and quality of fixation are known risk factors for osteolysis, the

Decrease in particle-induced osteolysis in obese (ob/ob) mice.

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There may be variability in the susceptibility of different individuals to osteolysis from wear debris, and it is not clear whether some individuals may have a genetic predisposition for a more marked osteolytic response. The purpose of this study in mice was to determine whether genetically

Analysis of retrieved uncemented porous-coated acetabular components in patients with and without pelvic osteolysis.

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Retrieved polyethylene liners and femoral heads from a consecutive series of revision components of one design were examined. All patients had Long-Term Stable Fixation (OsteoTechnology International, Timonium, Md) total hip arthroplasties (THAs) implanted between 1987 and 1992. The retrieved

Catastrophic osteolysis in total knee replacement. A report of 17 cases.

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One hundred eighty-five total knee revisions were done by the 2 senior authors from 1988 to 1994. Of these, 17 patients were identified as having severe osteolysis. The average age was 62.7 years, and the average weight was 90.8 g. All patients had osteoarthritis. Preoperative aspiration was

All-polyethylene tibial components in obese patients are associated with low failure at midterm followup.

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BACKGROUND In the United States, the obese population has increased markedly over the last four decades, and this trend continues. High patient weight places additional stress on TKA components, which may lead to increased polyethylene wear, osteolysis, radiolucencies, and clinical failure.

The impact of obesity on the mid-term outcome of cementless total knee replacement.

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We evaluated 535 consecutive primary cementless total knee replacements (TKR). The mean follow-up was 9.2 years (0.3 to 12.9) and information on implant survival was available for all patients. Patients were divided into two groups: 153 obese patients (BMI > or = 30) and 382 non-obese (BMI < 30). A

The effect of obesity on the mid-term survival and clinical outcome of cementless total hip replacement.

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The outcome of total hip replacement (THR) is potentially affected by the body mass index (BMI) of the patient. We studied the outcome of 2026 consecutive primary cementless THRs performed for osteoarthritis. The mean follow-up was 6.3 years (0 to 11.71) and no patient was lost to follow-up for

Long-term outcome of total knee replacement: does obesity matter?

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BACKGROUND Although arthritic complications are common in the obese, many surgeons are reluctant to perform joint replacements in this population. We compared outcomes of total knee arthroplasties (TKAs) in normal weight and obese patients. METHODS 30 TKAs in 21 obese patients with BMI 30-49 (Group

Leptin Increases Particle-Induced Osteolysis in Female ob/ob Mice.

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Particles generated from wear of prosthesis joint bearing surfaces induce inflammation-mediated periprosthetic bone resorption (osteolysis). Morbidly obese leptin-deficient ob/ob mice are resistant to polyethylene particle-induced bone loss, suggesting that leptin, a hormone produced by adipocytes

The influence of obesity on primary total hip arthroplasty outcomes: A meta-analysis of prospective cohort studies.

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BACKGROUND Whether or not, obesity negatively influencing the outcomes of primary total hip arthroplasty (THA) remains a controversial issue. Though observational studies focused on this topic, the reported conclusions remain inconsistent. Therefore, we performed a meta-analysis of prospective

Obesity in total hip replacement.

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A prospective, multi-centre study was carried out on 1421 total hip replacements between January 1999 and July 2007 to examine if obesity has an effect on clinical outcomes. The patients were categorised into three groups: non-obese (body mass index (BMI) < 30 kg/m(2)), obese (BMI 30 to 40 kg/m(2))

The outcome of total hip replacement in obese and non-obese patients at 10- to 18-years.

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We studied a consecutive series of 285 uncemented total hip replacements in 260 patients using the Taperloc femoral component and the T-Tap acetabular component. The outcome of every hip was determined in both living and deceased patients. A complete clinical and radiological follow-up was obtained

Patellar osteolysis after total knee arthroplasty with patellar resurfacing: a potentially underappreciated problem.

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Osteolysis of the patella following total knee arthroplasty is both uncommon and poorly described in the literature. We describe 3 cases of total knee arthroplasty with patella resurfacing that later presented with anterior knee pain with patellar osteolysis without evidence of patellar implant

Tibial baseplate fracture associated with polyethylene wear and osteolysis after total knee arthroplasty.

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BACKGROUND Fracture of the tibial baseplate following total knee arthroplasty is very rare given the developments in modern prosthesis design. Tibial baseplate fracture secondary to polyethylene wear, osteolysis and component malalignment in an elderly obese patient is reported in the present

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