Product: Red ginseng Everytime 1 pack(3g/day)

Climacteric Symptoms

Take one pack of the product (3g) once a day for 24 weeks

Korean Red Ginseng

Red Ginseng Extract With Climacteric Symptoms

A 24-week, Single-center, Open-label Study to Evaluate Gut Microbiota, Immunity, Oxidative Stress and Autonomic Nerve System of Red Ginseng Extract in Subjects With Climacteric Symptoms.

MedicalExcellence

tablets (2 tablets/day, 125 mg & 500 mg/day) for 12 weeks.

Fatty Liver, Nonalcoholic

fermented ginseng powder

Placebo

Clinical Trial Center for Functional Foods Chonbuk National University Hospital

Efficacy and Safety of Fermented Ginseng Powder on Liver Function

A 12-week, Randomized, Double-blind, Placebo-controlled Human Trial to Evaluate the Efficacy and Safety of Fermented Ginseng Powder on Liver Function

Changes of ALT were assessed before and after the intervention

Changes of AST were assessed before and after the intervention

Changes of fatty liver grade were assessed before and after the intervention

Changes of lipid metabolism index were assessed before and after the intervention

Changes of total antioxidant capacity were assessed before and after the intervention

Changes of imflammation index were assessed before and after the intervention

Changes of Multidimensional Fatigue Scale were assessed before and after the intervention

Soo-Wan Chae

Principal Investigator, Clinical Trial Center for Functional Foods

Chonbuk National University Hospital

People in this group take a red ginseng powder capsule.

People in this group take a placebo powder capsule.

Chronic Fatigue Syndrome

usage : 3C bid ac 30min dose : total 3g for 1day drug administration : oral administration administration session : 6weeks

red ginseng powder capsule

Control (Placebo) : red ginseng powder capsule(placebo) usage : 3C bid ac 30min dose : total 3g for 1day drug administration : oral administration administration session : 6weeks

Dongguk university Bundang Oriental Hospital

A Clinical Study About Improvement of Chronic Fatigue After Taking Red Ginseng

The patient is asked to indicate their perceived fatigue intensity along a 100 mm horizontal line, where '0' represents 'no fatigue' and '100', 'unbearable fatigue'

The FSS is a self-administered questionnaire with 9 items (questions) investigating the severity of fatigue in different situations during the past week. Grading of each item ranges from 1 to 7, where 1 indicates strong disagreement and 7 strong agreement, and the final score represents the mean value of the 9 items

The Chalder fatigue severity questionnaire is composed of 11 questions about fatigue. Grading of each item ranges from 0 to 9, where 0 indicate non-fatigue and 9 strong fatigue

SRI-short form is composed of 22 items about stress response. 22 items are classified into three categories(Somatization,anger and depression).

When the test is scored, a value of 0 to 3 is assigned for each answer and then the total score is compared to a key to determine the depression's severity.

The ISI is composed of seven items assessing recent problems with sleep onset, sleep maintenance and early morning awakening, interference of sleep problems with daily functioning and perceived prominence of impairment attributed to the sleep problem, concern about sleep problems and satisfaction with sleep patterns. Perceived severity of each item is rated on a 0-4 scale and a total score, which ranges from 0 to 28 obtains from summing the items ratings

The EuroQOL - 5 Dimensions (EQ-5D) was employed for measuring health-related quality of life. It consisted of a weighted sum of five dimensions: Mobility, Self-care, Usual activities, Pain/Discomfort and Anxiety/Depression, which provided a simple descriptive profile and a single index value for health status . We used a recently developed version, the EQ-5D-5L, which includes five-level response options: no problems, slight problems, moderate problems, severe problems, and extreme problems

measure cortisol level in saliva
First saliva sample : 07:00-09:00 (within 30 minutes after waking up)
Second saliva sample :
11:00-13:00
Third saliva sample :
16:00-18:00
fourth saliva sample : 22:00-00:00

ginseng subjective symptoms questionnaire is composed of 13 items about subjective symptoms after taking red ginseng

Eun Jung Kim

Assistant professor

KRG capsule (3,000 mg/day) for 3 weeks
KRG (Korea Red ginseng): 3 weeks of KRG capsule (3,000 mg/day)

Korea Red Ginseng (KRG)

placebo (for KRG) for 3 weeks
Placebo (for KRG): Placebos with same shape and size were manufactured and at Korea Ginseng Corporation

Placebo (for KRG)

Total

Sex: Female, Male

Region of Enrollment

aspartate aminotransferase, alanine aminotransferase, gamma glutamyl transferase, lactate dehydrogenase

Liver Enzymes

KRUPP's fatigue severity scale.
The survey has nine questions as following:
my motivation is lower, when I am fatigued
exercise brings on my fatigue
I am easily fatigued
fatigue interferes with my physical functioning
fatigue causes frequent problems for me
my fatigue prevents sustained physical functioning
fatigue interferes with carrying out certain duties and responsibilities
fatigue is among my 3 most disabling symptoms
fatigue interferes with my work, family, or social life. All subjects scored each question on a 7-point scale (1 = strongly disagree to 4 = neither disagree nor agree to 7 = strongly agree).
Scores range from 9 to 63, with higher scores indicating higher fatigue

Fatigue as Measured by KRUPP's Fatigue Severity Scale

tumor necrosis factor-alpha, interleukin-6

Pro-inflammatory Cytokine

Adiponectin

Overall Study

Dr. Ki Tae Suk

Fatigue

KRG (Korea Red ginseng)

Placebos with same shape and size were manufactured and at Korea Ginseng Corporation

Anti-fatigue Effect of Korean Red Ginseng in Patients With Non-alcoholic Hepatitis

Ki Tae Suk

doctor, assistant professor

Chuncheon Sacred Heart Hospital

three capsules of KRG (500 mg/dose) daily and varicocelectomy.

three capsules of KRG (500 mg/dose) daily

non-V + P group (n = 20) placebo capsules

Male Infertility

The KRG capsules were provided by Korean Ginseng Corporation (Daejeon, Korea). KRG powder was manufactured from roots of a 6-year-old red ginseng, Panax ginseng Meyer, harvested in Republic of Korea. KRG was made by steaming fresh ginseng at 90-100 ◦C for 3 h and then drying at 50-80 ◦C.
KRG powder prepared from grinded red ginseng (KRG capsule : 500mg/capsule). KRG was analyzed by high-performance liquid chromatography. KRG extract contained major ginsenoside-Rb1: 4.26mg/g, -Rb2: 1.62mg/g, -Rc: 1.80mg/g, -Rd: 0.29mg/g, -Re: 1.71mg/g, -Rf: 0.67mg/g, -Rg1: 2.61mg/g, -Rg2: 0.20mg/g, -Rg3: 0.13mg/g, and other minor ginsenosides. During the study period, three capsules were taken daily for 12 weeks.

Korean Red Ginseng (KRG)

Surgical microscope-assisted varicocelectomy using the subinguinal approach was conducted by a single surgeon.

Varicocelectomy

Department of Urology, Pusan National University Hospital

Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study

1) sperm concentration, 2) percent motility, 3) sperm viability, and 4) Kruger/strict morphology using World Health Organization (WHO) methodologies (4th edition).

Serum concentrations of FSH and LH were measured using chemiluminescence assays, and serum total testosterone was quantified by radioimmunoassay. The hormonal status of all patients was recorded at the initial screening visit and post-treatment.

panax stipuleanatus/antioxidante

Red Ginseng Extract With Climacteric Symptoms

Efficacy and Safety of Fermented Ginseng Powder on Liver Function

A Clinical Study About Improvement of Chronic Fatigue After Taking Red Ginseng

Anti-fatigue Effect of Korean Red Ginseng in Patients With Non-alcoholic Hepatitis

Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study

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