The present application describes compounds according to Formula I, wherein A, G.sup.1, G.sup.2 and R.sup.1 are described herein. Additionally, the present application describes pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents. Finally, the present application describes methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents ##STR00001##

Bristol-Myers Squibb Company

Pyrazine modulators of cannabinoid receptors

The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I ##STR00001## Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.

pyrazine/cannabis

Pyrazine modulators of cannabinoid receptors

Substituted imidazo[1,5-a][1,4]diazepines and imidazo[1,5-a]pyrazines as cannabinoid receptor agonists for the treatment of pain

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