Patient with hypermetabolic response of skeletal musculature by causes related with Malignant Hyperthermia in the literature.

50 variants have been described that can be considered "diagnostic mutations" of RYR1 and CACNA1S, and other under study.

Hyperthermia, Malignant

In vitro study of muscle contraction after exposure to different substances (caffeine and halothane).

In vitro contracture test (IVCT)

In vitro study of the activation of lymphocytes B after being incubated with a cocktail of primary antibodies and measuring the acidification in response to the RyR1, 4-CmC agonist, using ryanodine as a positive control.

In vitro test of hypermetabolism in B lymphocytes

Analysis of genes related to MH (CACNA1S and RYR1).

Genetic test

Hospital Universitario La Paz

Population at Risk of Malignant Hyperthermia: Ambispective Cohort.

Measured by the tension induced by the muscular contraction in response to the presence of caffeine and halothane.

Identifying determined genes related with Malignant Hyperthermia risk.

Extracellular acidification curve in B lymphocytes in response to the agonist RyR1 and 4-CmC.

Instituto de Investigación Hospital Universitario La Paz

Universidad Autonoma de Madrid

Patients > 18 years of age with acute kidney injury were enroled into the study. Arterial levels of neutrophil gelatinase-associated lipocalin (NGAL), arterial lactate, interleukin-6 (IL-6), procalcitonin (PCT) and myoglobin were investigated in all patients.

Acute Kidney Injury

Blood neutrophil gelatinase-associated lipocalin (NGAL) test was performed in all patients.

Neutrophil gelatinase-associated lipocalin (NGAL)

Arterial lactate level was assessed in all patients.

Arterial lactate

The level of interleukin-6 was assessed in all patients.

Interleukin-6 (IL-6)

The level of procalcitonin (PCT) was assessed in all patients.

Procalcitonin (PCT)

The level of myoglobin was assessed in all patients.

Myoglobin

University Hospital Ostrava

Acute Kidney Injury in Severe Trauma

Incidence, Prediction and Time-dependent Role of Risk Factors of Acute Kidney Injury in Severe Trauma: Prospective Observational Cohort Study

The main goal of the study was to evaluate the validity of AKI biomarker neutrophil gelatinase-associated lipocalin in AKI prediction in severely injured patients with Injury Severity Score (ISS) > 24.

Secondary outcome measure was to determine the time-dependend role of insults associated directly with intensity of injury (tissue hypoxia, systemic inflammatory response and/or infection, rhabdomyolysis) in the pathopfysiology of AKI.

Rhabdomyolysis

Groupe Hospitalier Paris Saint Joseph

Support for the Rhabdomyolysis in an Emergency Department

Detect the most common complications of Hour 0 support and evolution Hour 48 if the patient not transferred. Hour 0 support and evolution at Hour 48

rhabdomyolysis/hypoxia

Population at Risk of Malignant Hyperthermia: Ambispective Cohort.

Acute Kidney Injury in Severe Trauma

Support for the Rhabdomyolysis in an Emergency Department

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