rosmarinic acid/hepatite

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Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction.

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Current therapeutics for hepatitis B virus (HBV) patients such as nucleoside analogs (NAs) are effective; however, new antiviral drugs against HBV are still desired. Since the interaction between the epsilon (ε) sequence of HBV pregenomic RNA and viral polymerase (Pol) is a key step in the HBV

Rosmarinic acid protects mice from Concanavalin A-induced hepatic injury through AMPK signaling

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Rosmarinic acid (RA) is extensively utilized in herbal medicine in China. The adenosine 5'-monophosphate-activated protein kinase (AMPK) signaling can be activated by RA and inhibited by the synthetic, reversible AMP-competitive inhibitor, Compound C (CC). The objective of this study was to

Rosmarinic acid Ameliorates H2O2-Induced Oxidative Stress On L02 Cells through MAPK and Nrf2 Pathways.

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Liver cells are easy to be damaged by oxidative stress during the progression both liver development and throughout adult life, resulting in tissue pathology which ranges from simple hepatitis to non-alcoholic fatty liver disease (NAFLD). Here, we determined the attenuation of oxidative stress on

Hepatoprotective effects of rosmarinic acid: Insight into its mechanisms of action.

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Liver diseases such as hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma are one of the major health challenges in the world and many conditions such as inadequate nutrition, viral infection, ethanol and drug abuse, xenobiotic exposure, and metabolic diseases have been implicated in the

Anti-hepatitis, antioxidant activities and bioactive compounds of Dracocephalum heterophyllum extracts.

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BACKGROUND Dracocephalum heterophyllum was a traditional Tibetan medicine possesses various pharmacological effects involved in anti-inflammatory, antibacterial activities. However, its anti-hepatitis, antioxidant activity and bioactive compounds have not been reported, the objective of this

Investigation of the absorbed and metabolized components of Danshen from Fuzheng Huayu recipe and study on the anti-hepatic fibrosis effects of these components.

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BACKGROUND Fuzheng Huayu recipe (FZHY) was formulated on the basis of Chinese medicine theory in treating liver fibrosis. It has a significant efficacy against liver fibrosis caused by chronic hepatitis B, with the action mechanisms of inhibition of hepatic stellate cell activation, protection of

Antiviral activities of compounds from aerial parts of Salvia plebeia R. Br.

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BACKGROUND Salvia plebeia R. Br. is an edible plant widely spread in many countries. It has been used as a traditional medicine to treat common cold, flu, cough, hepatitis, hemorrhoids, etc. The purpose of the study is to explicate antiviral compounds responsible for its traditional use for the

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