securinine/flueggea

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L-securinine inhibits the proliferation of A549 lung cancer cells and promotes DKK1 promoter methylation.

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L-securinine is a natural product extracted and isolated from the leaf of dried Securinega suffruticosa. The aim of the present study was to explore the effects of L-securinine on proliferation, and the methylation profile of the dickkopf-related protein 1 (DKK1) gene in human lung cancer cells and

Securinine suppresses osteoclastogenesis and ameliorates inflammatory bone loss

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Securinine (Sec) is a naturally derived compound separated from the roots of Securinega suffruticosa, which has long been used as a herbal medicine. Sec is widely known as a GABA receptor antagonist, it is also known as an innate immune cell agonist and has been reported to increase macrophage

Development and validation of LC-MS/MS method for quantitative determination of (-)-securinine in mouse plasma.

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(-)-Securinine (SE) is a major alkaloid found in plant Securinega suffruticosa, which has a wide range of pharmacological activities including anticancer, anti-parasitic and central nervous system stimulating effects, etc. To aid the pharmacological study of SE, we developed an LC-MS/MS method for

Antiproliferative activity and apoptosis-inducing mechanism of L-securinine on human breast cancer MCF-7 cells.

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Natural products have been discovered to be valuable sources of antitumor drugs. L-Securinine is a natural product extracted from the leaves or roots of Securinega suffruticosa Pall Rehd. The current study was done to investigate the molecular mechanisms of antitumor effects of L-securinine. The

Flueggeacosines A-C, Dimeric Securinine-Type Alkaloid Analogues with Neuronal Differentiation Activity from Flueggea suffruticosa.

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Flueggeacosines A-C (1-3), three dimeric securinine-type alkaloid analogues with unprecedented skeletons, were isolated from Flueggea suffruticosa. Compounds 1 and 2 are the first examples of C-3-C-15' connected dimeric securinine-type alkaloids. Compound 3 is an unprecedented heterodimer of

Toxoplasma gondii: inhibitory activity and encystation effect of securinine and pyrrolidine derivatives on Toxoplasma growth.

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Securinine, an alkaloid originally isolated from Securinega suffruticosa, exhibits a wide range of biological activities, including anti-malarial activity. Along with securinine, 10 pyrrolidine derivatives, generated via the retrosynthesis of (-)-securinine, were selected and tested for their

Securinine disturbs redox homeostasis and elicits oxidative stress-mediated apoptosis via targeting thioredoxin reductase.

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Thioredoxin reductase (TrxR) and thioredoxin (Trx) are two major components of the thioredoxin system, which plays essential roles in regulating cellular redox signaling. Mammalian TrxRs are essential seleno-flavoenzymes with a conserved penultimate selenocysteine (Sec) residue at the C-terminus,

Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson's Disease.

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Glial activation and subsequent release of neurotoxic proinflammatory factors are believed to play an important role in the pathogenesis of several neurological disorders including Parkinson's disease (PD). Inhibition of glial activation and inflammatory processes may represent a therapeutic target

[Cultivation experiments of securinega suffruticosa Rehd. as securinine source. IV].

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[Cultivation experiments of Securinega suffruticosa Rehd, as securinine source. II].

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[Cultivation experiments of Securinega suffruticosa Rehd, as securinine source. 3].

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[STUDIES ON SECURININE. II. ISOLATION OF DIHYDROSECURININE FROM SECURINEGA SUFFRUTICOSA (PALL.) REHD].

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[Experiment on cultivation of Securinega suffruticosa Rehd., the source of securinine. 1].

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[STUDIES ON THE EXTRACTION AND ISOLATION OF SECURININE FROM SECURINEGA SUFFRUTICOSA (PALL.) REHD. BY ADSORPTION WITH ACTIVE CARBON].

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[Experiments on the cultivation of plants containing securinine in Izu, Japan. 1. Comparison of the growth of Securinega suffruticosa Rehder at sunny and shady places].

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